[The correction of the vaginal microflora in patients with a papillomavirus infection associated with cervical intraepithelial neoplasia by using the new bacterial preparation Zhlemik]. / Korrektsiia vaginal'noi mikroflory u bol'nykh s papillomavirusnoi infektsiei v assotsiatsii s tservikal'noi intraépitelial'noi neoplaziei s pomoshch'iu novogo bakteriinogo preparata "Zhlemik".

The microbiological study of vaginal microflora in 40 patients of the reproductive age (20-30 years) with papilloma virus infection in association with cervical intraepithelial neoplasia of the uterine neck revealed dysbiotic disturbances in vaginal microflora, manifested by a decrease in the isolation rate and amount of lacto- and bifidobacteria and by excessive growth of opportunistic microorganisms. The 10-day course of corrective therapy with the new bacterial preparation "Zhlemik" was carried out. Group 1 (81 women) received the preparation intravaginally on a tampon, group 2 (19 patients) received the preparation in the form of vaginal suppositories. The results of this treatment were indicative of a high sanative effect of the preparation irrespective of the method of its application. This was demonstrated by the results of the bacteriological study made after bacterial correction: the amount of the Lactobacillus was restored, and they could be isolated from all patients; the level of contamination of the cervicovaginal niche with opportunistic microbial strains considerably decreased. The positive clinical effect after bacterial therapy with "Zhlemik" was observed in 93-95% of cases, depending on the form of its application.

[The genital tract microflora in patients with a papillomavirus infection]. / Mikroflora genital'nogo trakta u bol'nykh s papillomavirusnoi infektsiei.

In 70 patients of reproductive age (20-30 years) with the papilloma virus infection of the uterine neck the microflora of vaginal contents was studied. The study revealed the specific diversity of bacteria colonizing the vagina and the uterine neck. High occurrence of Chlamydia and Gardnerella was established. The detected dysbiotic disturbances in patients with condylomatosis of the uterine neck were manifested by a decrease in the isolation rate of lactobacteria and bifidobacteria and by an increase in the isolation rate of opportunistic bacteria. The most pronounced dysbiosis in the microflora of the vagina and the uterine neck was characteristic of patients with papilloma virus infection in association with cervical intraepithelial neoplasia of the III degree.

[The effect of SolcoTrichovac on the vaginal microflora of patients with a papillomavirus infection associated with a cervical intraepithelial neoplasm]. / Izuchenie vliianiia "Solkotrikhovaka" na vaginal'nuiu mikrofloru u bol'nykh s papillomavirusnoi infektsiei v assotsiatsii s tservikal'noi intraépitelial'noi neoplaziei.

The microbiological study of vaginal secretions of 39 female patients of reproductive age (20-30 years) with papilloma virus infection associated with cervical intraepithelial neoplasia (CIN) was carried out. Of these patients, 28 with papilloma virus infection associated with CINI-II made up group I and II having this infection associated with CINII made up group 2. Dysbiotic disturbances in vaginal bacterial flora, found in these patients, were manifested by a decrease in the isolation rate and number of the lacto- and bifidobacteria simultaneously with the excessive growth of opportunistic bacteria. The results of the oral administration of Solco-Trichovac are indicative of the effectiveness of this preparation, which was confirmed by the data of clinical and bacteriological studies. Together with an increase in the isolation rate of lacto- and bifidobacteria, the level of the contamination of the cervicovaginal niche with opportunistic and pathogenic bacterial strains decreased. The results thus obtained make it possible to recommend Solco-Trichovac for the complex treatment of with papilloma virus infection associated with CIN.