RESUMO
PURPOSE: To assess the effectiveness of the medicine Ophtalmoferon (eye drops) in the treatment of conjunctivitis of mixed aetiology in patients with first-time tuberculosis (TB) and human immunodeficiency virus (HIV) infection, who have been treated at the Clinical Anti-tuberculosis Hospital No. 4. MATERIAL AND METHODS: The study included 60 patients (42 men and 18 women with mean age of 41.48±1.34 years), who had consulted the ophthalmologist for conjunctivitis. The patients were divided into two groups: the first group - main one (n=32) - received complex local therapy with the medicine Ophtalmoferon; the second group (n=28) - control one - did not receive Ophtalmoferon as a part of complex local treatment. The treatment involved assessment of the effectiveness, tolerability and safety of the examined medicine. RESULTS: Patient examinations were conducted on the first visit, then on the third, fifth and seventh day of treatment. On the third day of treatment as compared to the baseline the burning sensation and pain in the eyes were less severe; in the main group that received the medicine Ophtalmoferon (group 1) the number of patients describing these symptoms as mild (1 point) were 15.6% (pain) and 18.8% (burning), respectively (W=2.15; p=0.03). Severe lacrimation (3 points) remained in 5 (15.6%) patients. On the fifth day there were no main group patients with severe (3 points) or moderate (2 points) lacrimation. On the seventh day complete resolution of subjective symptoms was noted in 71.9% (group 1) and 42.9% (group 2) of patients (χ2=1.39; p=0.238), respectively. There was no lacrimation in 71.9% (group 1) and 35.7% (group 2) of patients (χ2=2.36; p=0.125), no eye redness was noted in 78.1% (group 1) and 28.6% (group 2) of patients (χ2=4.51; p=0.034), respectively. CONCLUSION: The use of the combined medicine Ophtalmoferon in the complex local treatment of conjunctivitis of mixed aetiology in patients with tuberculosis and HIV infection helps to achieve a rapid relief of subjective and objective symptoms with good tolerability of the medicine.
Assuntos
Conjuntivite Alérgica , Conjuntivite , Infecções por HIV , Tuberculose , Adulto , Feminino , Humanos , Masculino , Soluções Oftálmicas , Resultado do TratamentoRESUMO
Chronic obstructive pulmonary disease (COPD) and tuberculosis are socially significant diseases that can develop at any age, and require long-term, sometimes lifelong, therapy. Diseases will inevitably cause a deficiency of oxygen in the body that can cause disorders of the nervous system, from the mood changes to reduce intelligence, especially in the elderly. According to the results of the study the majority of patients with COPD and a third of patients with tuberculosis, there are significant problems of the emotional plane, especially in older and elderly expressed in the presence of depressive tendencies (from subdepressive states to real depression), and almost half of the patients in need of specially organized psychological or medical assistance.
Assuntos
Doença Pulmonar Obstrutiva Crônica , Tuberculose , Depressão , Transtorno Depressivo , HumanosRESUMO
Disseminated intestinal and cutaneous thromboangiitis (Kohlmeier-Degos' syndrome) is a rare syndrome of unknown etiology, which is characterized by cutaneous and visceral involvement. Two (cutaneous and visceral) stages are identified. A fatal outcome is inevitable although there may be a long (8-20-year) course of the disease during a benign process. The causes of death are peritonitis, central nervous system impairments, pleurisy, pericarditis. The paper describes a case of disseminated intestinal and cutaneous thromboangiitis (Kohlmeier-Degos' syndrome) in a 32-year-old female patient who has died from intoxication due to severely impaired permeability of the epithelial barrier mainly of the large bowel (diphtheritic inflammation of the mucosa, severe inflammatory edema of the submucous layer, and fibrinous impregnation of the serous membrane).
