Classification of cancer types based on microRNA expression using a hybrid radial basis function and particle swarm optimization algorithm.

The diagnosis and treatment of cancer is one of the most challenging aspects of the medical profession, despite advances in disease diagnosis. MicroRNAs are small noncoding RNA molecules involved in regulating gene expression and are associated with several cancer types. Therefore, the analysis of microRNA data has become one of the most important areas of cancer research in recent years. This paper presents an improved method for cancer-type classification based on microRNA expression data using a hybrid radial basis function (RBF) and particle swarm optimization (PSO) algorithm. Two datasets containing microRNA information were used, and preprocessing and normalization operations were performed on the raw data. Feature selection was carried out by using the PSO algorithm, which can identify the most relevant and informative features in the data along with helping to prioritize them. Using a PSO algorithm for feature selection is an effective approach to microRNA analysis. This enhances the accuracy and reliability of cancer-type classifications based on microRNA expression data. In the proposed method, we, respectively, achieved an accuracy of 0.95% and 0.91% on both datasets, with an average of 0.93%, using an improved RBF neural network classifier. These results demonstrate that the proposed method outperforms previous works. RESEARCH HIGHLIGHTS: To enhance the accuracy of cancer-type classifications based on microRNA expression data. We present a minimal feature selection method using particle swarm optimization to reduce computational load & radial basis function to improve accuracy.

Early pigment spot segmentation and classification from iris cellular image analysis with explainable deep learning and multiclass support vector machine.

Globally, retinal disorders impact thousands of individuals. Early diagnosis and treatment of these anomalies might halt their development and prevent many people from developing preventable blindness. Iris spot segmentation is critical due to acquiring iris cellular images that suffer from the off-angle iris, noise, and specular reflection. Most currently used iris segmentation techniques are based on edge data and noncellular images. The size of the pigment patches on the surface of the iris increases with eye syndrome. In addition, iris images taken in uncooperative settings frequently have negative noise, making it difficult to segment them precisely. The traditional diagnosis processes are costly and time consuming since they require highly qualified personnel and have strict environments. This paper presents an explainable deep learning model integrated with a multiclass support vector machine to analyze iris cellular images for early pigment spot segmentation and classification. Three benchmark datasets MILE, UPOL, and Eyes SUB were used in the experiments to test the proposed methodology. The experimental results are compared on standard metrics, demonstrating that the proposed model outperformed the methods reported in the literature regarding classification errors. Additionally, it is observed that the proposed parameters are highly effective in locating the micro pigment spots on the iris surfaces.

An Explainable AI-Enabled Framework for Interpreting Pulmonary Diseases from Chest Radiographs.

Explainable Artificial Intelligence is a key component of artificially intelligent systems that aim to explain the classification results. The classification results explanation is essential for automatic disease diagnosis in healthcare. The human respiration system is badly affected by different chest pulmonary diseases. Automatic classification and explanation can be used to detect these lung diseases. In this paper, we introduced a CNN-based transfer learning-based approach for automatically explaining pulmonary diseases, i.e., edema, tuberculosis, nodules, and pneumonia from chest radiographs. Among these pulmonary diseases, pneumonia, which COVID-19 causes, is deadly; therefore, radiographs of COVID-19 are used for the explanation task. We used the ResNet50 neural network and trained the network on extensive training with the COVID-CT dataset and the COVIDNet dataset. The interpretable model LIME is used for the explanation of classification results. Lime highlights the input image's important features for generating the classification result. We evaluated the explanation using radiologists' highlighted images and identified that our model highlights and explains the same regions. We achieved improved classification results with our fine-tuned model with an accuracy of 93% and 97%, respectively. The analysis of our results indicates that this research not only improves the classification results but also provides an explanation of pulmonary diseases with advanced deep-learning methods. This research would assist radiologists with automatic disease detection and explanations, which are used to make clinical decisions and assist in diagnosing and treating pulmonary diseases in the early stage.

A hybrid intelligent model for early validation of infectious diseases: An explorative study of machine learning approaches.

Literature reports several infectious diseases news validation approaches, but none is economically effective for collecting and classifying information on different infectious diseases. This work presents a hybrid machine-learning model that could predict the validity of the infectious disease's news spread on the media. The proposed hybrid machine learning (ML) model uses the Dynamic Classifier Selection (DCS) process to validate news. Several machine learning models, such as K-Neighbors-Neighbor (KNN), AdaBoost (AB), Decision Tree (DT), Random Forest (RF), SVC, Gaussian Naïve Base (GNB), and Logistic Regression (LR) are tested in the simulation process on benchmark dataset. The simulation employs three DCS process methods: overall Local Accuracy (OLA), Meta Dynamic ensemble selection (META-DES), and Bagging. From seven ML classifiers, the AdaBoost with Bagging DCS method got a 97.45% high accuracy rate for training samples and a 97.56% high accuracy rate for testing samples. The second high accuracy was obtained at 96.12% for training and 96.45% for testing samples from AdaBoost with the Meta-DES method. Overall, the AdaBoost with Bagging model obtained higher accuracy, AUC, sensitivity, and specificity rate with minimum FPR and FNR for validation.

Efficient and trusted autonomous vehicle routing protocol for 6G networks with computational intelligence.

The Internet of Things (IoT) and wireless sensors have collaborated with many real-time environments for the collection and processing of physical data. Mobile networks with sixth-generation (6G) technologies provide support for emerging applications using Connected and Autonomous Vehicles (CAV) and observe critical conditions. Although, autonomous vehicle-based routing solutions have presented significant development toward reliable and inter-vehicle communications. However, there are numerous research obstacles in terms of data delivery and transmission latency due to the unpredictable environment and changing states of IoT sensors. Therefore, this work presents an efficient and trusted autonomous vehicle routing protocol using 6G networks, which aims to guarantee high quality of service and data coverage. Firstly, the proposed protocol establishes a routing process using a simulated annealing optimization technique and improves energy optimization between IoT-based vehicles, and under difficult circumstances, it statistically guarantees the optimal solution. Secondly, it provides a risk-aware security system due to reliable session-oriented communication with network edges among connected vehicles and avoids uncertainties in the autonomous system. The proposed protocol is verified using simulations for varying vehicles and varying iterations that indicates a green communication system for the autonomous system with authenticity and system intelligence.

Secure Edge-Based Energy Management Protocol in Smart Grid Environments with Correlation Analysis.

For the monitoring and processing of network data, wireless systems are widely used in many industrial applications. With the assistance of wireless sensor networks (WSNs) and the Internet of Things (IoT), smart grids are being explored in many distributed communication systems. They collect data from the surrounding environment and transmit it with the support of a multi-hop system. However, there is still a significant research gap in energy management for IoT devices and smart sensors. Many solutions have been proposed by researchers to cope with efficient routing schemes in smart grid applications. But, reducing energy holes and offering intelligent decisions for forwarding data are remain major problems. Moreover, the management of network traffic on grid nodes while balancing the communication overhead on the routing paths is an also demanding challenge. In this research work, we propose a secure edge-based energy management protocol for a smart grid environment with the support of multi-route management. It strengthens the ability to predict the data forwarding process and improves the management of IoT devices by utilizing a technique of correlation analysis. Moreover, the proposed protocol increases the system's reliability and achieves security goals by employing lightweight authentication with sink coordination. To demonstrate the superiority of our proposed protocol over the chosen existing work, extensive experiments were performed on various network parameters.

Identification of Anomalies in Mammograms through Internet of Medical Things (IoMT) Diagnosis System.

Breast cancer is the primary health issue that women may face at some point in their lifetime. This may lead to death in severe cases. A mammography procedure is used for finding suspicious masses in the breast. Teleradiology is employed for online treatment and diagnostics processes due to the unavailability and shortage of trained radiologists in backward and remote areas. The availability of online radiologists is uncertain due to inadequate network coverage in rural areas. In such circumstances, the Computer-Aided Diagnosis (CAD) framework is useful for identifying breast abnormalities without expert radiologists. This research presents a decision-making system based on IoMT (Internet of Medical Things) to identify breast anomalies. The proposed technique encompasses the region growing algorithm to segment tumor that extracts suspicious part. Then, texture and shape-based features are employed to characterize breast lesions. The extracted features include first and second-order statistics, center-symmetric local binary pattern (CS-LBP), a histogram of oriented gradients (HOG), and shape-based techniques used to obtain various features from the mammograms. Finally, a fusion of machine learning algorithms including K-Nearest Neighbor (KNN), Support Vector Machine (SVM), and Linear Discriminant Analysis (LDA are employed to classify breast cancer using composite feature vectors. The experimental results exhibit the proposed framework's efficacy that separates the cancerous lesions from the benign ones using 10-fold cross-validations. The accuracy, sensitivity, and specificity attained are 96.3%, 94.1%, and 98.2%, respectively, through shape-based features from the MIAS database. Finally, this research contributes a model with the ability for earlier and improved accuracy of breast tumor detection.

Sustainable Data-Driven Secured Optimization Using Dynamic Programming for Green Internet of Things.

The development of smart applications has benefited greatly from the expansion of wireless technologies. A range of tasks are performed, and end devices are made capable of communicating with one another with the support of artificial intelligence technology. The Internet of Things (IoT) increases the efficiency of communication networks due to its low costs and simple management. However, it has been demonstrated that many systems still need an intelligent strategy for green computing. Establishing reliable connectivity in Green-IoT (G-IoT) networks is another key research challenge. With the integration of edge computing, this study provides a Sustainable Data-driven Secured optimization model (SDS-GIoT) that uses dynamic programming to provide enhanced learning capabilities. First, the proposed approach examines multi-variable functions and delivers graph-based link predictions to locate the optimal nodes for edge networks. Moreover, it identifies a sub-path in multistage to continue data transfer if a route is unavailable due to certain communication circumstances. Second, while applying security, edge computing provides offloading services that lower the amount of processing power needed for low-constraint nodes. Finally, the SDS-GIoT model is verified with various experiments, and the performance results demonstrate its significance for a sustainable environment against existing solutions.

Cloud Computing-Based Framework for Breast Tumor Image Classification Using Fusion of AlexNet and GLCM Texture Features with Ensemble Multi-Kernel Support Vector Machine (MK-SVM).

Breast cancer is common among women all over the world. Early identification of breast cancer lowers death rates. However, it is difficult to determine whether these are cancerous or noncancerous lesions due to their inconsistencies in image appearance. Machine learning techniques are widely employed in imaging analysis as a diagnostic method for breast cancer classification. However, patients cannot take advantage of remote areas as these systems are unavailable on clouds. Thus, breast cancer detection for remote patients is indispensable, which can only be possible through cloud computing. The user is allowed to feed images into the cloud system, which is further investigated through the computer aided diagnosis (CAD) system. Such systems could also be used to track patients, older adults, especially with disabilities, particularly in remote areas of developing countries that do not have medical facilities and paramedic staff. In the proposed CAD system, a fusion of AlexNet architecture and GLCM (gray-level cooccurrence matrix) features are used to extract distinguishable texture features from breast tissues. Finally, to attain higher precision, an ensemble of MK-SVM is used. For testing purposes, the proposed model is applied to the MIAS dataset, a commonly used breast image database, and achieved 96.26% accuracy.

Automatic skin lesions detection from images through microscopic hybrid features set and machine learning classifiers.

Skin cancer occurrences increase exponentially worldwide due to the lack of awareness of significant populations and skin specialists. Medical imaging can help with early detection and more accurate diagnosis of skin cancer. The physicians usually follow the manual diagnosis method in their clinics but nonprofessional dermatologists sometimes affect the accuracy of the results. Thus, the automated system is required to assist physicians in diagnosing skin cancer at early stage precisely to decrease the mortality rate. This article presents an automatic skin lesions detection through a microscopic hybrid feature set and machine learning-based classification. The employment of deep features through AlexNet architecture with local optimal-oriented pattern can accurately predict skin lesions. The proposed model is tested on two open-access datasets PAD-UFES-20 and MED-NODE comprising melanoma and nevus images. Experimental results on both datasets exhibit the efficacy of hybrid features with the help of machine learning. Finally, the proposed model achieved 94.7% accuracy using an ensemble classifier. RESEARCH HIGHLIGHTS: The deep features accurately predicted skin lesions through AlexNet architecture with local optimal-oriented pattern. Proposed model is tested on two datasets PAD-UFES-20, MED-NODE comprising melanoma, nevus images and exhibited high accuracy.

Arabic Speech Analysis for Classification and Prediction of Mental Illness due to Depression Using Deep Learning.

Depression is a global prevalent ailment for possible mental illness or mental disorder globally. Recognizing depressed early signs is critical for evaluating and preventing mental illness. With the progress of machine learning, it is possible to make intelligent systems capable of detecting depressive symptoms using speech analysis. This study presents a hybrid model to identify and predict mental illness from Arabic speech analysis due to depression. The proposed hybrid model comprises convolutional neural network (CNN) and a support vector machine (SVM) to identify and predict mental disorders. Experiments are performed on the Arabic speech benchmark data set of 200 speeches. A total of 70% of data were reserved for training, while 30% of data were to test the proposed model. The hybrid model (CNN + SVM) attained a 90.0% and 91.60% accuracy rate to predict the depression from Arabic speech analysis for training and testing stages. To authenticate the results of a proposed hybrid model, recurrent neural network (RNN) and CNN are also applied to the same data set individually, and the results are compared with each other. The RNN achieved an 80.70% and 81.60% accuracy rate to predict depression while speaking in the training and testing stages. The CNN predicted the depression in the training and testing stages with 88.50% and 86.60% accuracy rates. Based on the analysis, the proposed hybrid model secured better prediction results than individual RNN and CNN models on the same data set. Furthermore, the suggested model had a lower FPR, FNR, and higher accuracy, AUC, sensitivity, and specificity rate than individual RNN, CNN model performance in predicting depression. Finally, the achieved findings will be helpful to classify depression while speaking Arabic/speech and will be beneficial for physicians, psychiatrists, and psychologists in the detection of depression.

Device-to-Device (D2D) Multi-Criteria Learning Algorithm Using Secured Sensors.

Wireless networks and the Internet of things (IoT) have proven rapid growth in the development and management of smart environments. These technologies are applied in numerous research fields, such as security surveillance, Internet of vehicles, medical systems, etc. The sensor technologies and IoT devices are cooperative and allow the collection of unpredictable factors from the observing field. However, the constraint resources of distributed battery-powered sensors decrease the energy efficiency of the IoT network and increase the delay in receiving the network data on users' devices. It is observed that many solutions are proposed to overcome the energy deficiency in smart applications; though, due to the mobility of the nodes, lots of communication incurs frequent data discontinuity, compromising the data trust. Therefore, this work introduces a D2D multi-criteria learning algorithm for IoT networks using secured sensors, which aims to improve the data exchange without imposing additional costs and data diverting for mobile sensors. Moreover, it reduces the compromising threats in the presence of anonymous devices and increases the trustworthiness of the IoT-enabled communication system with the support of machine learning. The proposed work was tested and analyzed using broad simulation-based experiments and demonstrated the significantly improved performance of the packet delivery ratio by 17%, packet disturbances by 31%, data delay by 22%, energy consumption by 24%, and computational complexity by 37% for realistic network configurations.

Microscopic handcrafted features selection from computed tomography scans for early stage lungs cancer diagnosis using hybrid classifiers.

Lung's cancer is the leading cause of cancer-related deaths worldwide. Recently cancer mortality rate and incidence increased exponentially. Many patients with lung cancer are diagnosed late, so the survival rate is shallow. Machine learning approaches have been widely used to increase the effectiveness of cancer detection at an early stage. Even while these methods are efficient in detecting specific forms of cancer, there is no known technique that could be used universally and consistently to identify new malignancies. As a result, cancer diagnosis via machine learning algorithms is still fresh area of research. Computed tomography (CT) images are frequently employed for early cancer detection and diagnosis because they contain significant information. In this research, an automated lung cancer detection and classification framework is proposed which consists of preprocessing, three patches local binary pattern feature encoding, local binary pattern, histogram of oriented gradients features are extracted and fused. The fast learning network (FLN) is a novel machine-learning technique that is fast to train and economical in terms of processing resources. However, the FLN's internal power parameters (weight and basis) are randomly initialized, resulting it an unstable algorithm. Therefore, to enhance accuracy, FLN is hybrid with K-nearest neighbors to classify texture and appearance-based features of lung chest CT scans from Kaggle dataset into cancerous and non-cancerous images. The proposed model performance is evaluated using accuracy, sensitivity, specificity on the Kaggle benchmark dataset that is found comparable in state of the art using simple machine learning strategies. RESEARCH HIGHLIGHTS: Fast learning network and K-nearest neighbor hybrid classifier proposed first time for lung cancer classification using handcrafted features including three patches local binary pattern, local binary pattern, and histogram of oriented gradients. Promising results obtained from novel simple combination.

Detection of microscopic glaucoma through fundus images using deep transfer learning approach.

Glaucoma disease in humans can lead to blindness if it progresses to the point where it affects the oculus' optic nerve head. It is not easily detected since there are no symptoms, but it can be detected using tonometry, ophthalmoscopy, and perimeter. However, advances in artificial intelligence approaches have permitted machine learning techniques to diagnose at an early stage. Numerous methods have been proposed using Machine Learning to diagnose glaucoma with different data sets and techniques but these are complex methods. Although, medical imaging instruments are used as glaucoma screening methods, fundus imaging specifically is the most used screening technique for glaucoma detection. This study presents a novel DenseNet and DarkNet combination to classify normal and glaucoma affected fundus image. These frameworks have been trained and tested on three data sets of high-resolution fundus (HRF), RIM 1, and ACRIMA. A total of 658 images have been used for healthy eyes and 612 images for glaucoma-affected eyes classification. It has also been observed that the fusion of DenseNet and DarkNet outperforms the two CNN networks and achieved 99.7% accuracy, 98.9% sensitivity, 100% specificity for the HRF database. In contrast, for the RIM1 database, 89.3% accuracy, 93.3% sensitivity, 88.46% specificity has been attained. Moreover, for the ACRIMA database, 99% accuracy, 100% sensitivity, 99% specificity has been achieved. Therefore, the proposed method is robust and efficient with less computational time and complexity compared to the literature available.

Microscopic retinal blood vessels detection and segmentation using support vector machine and K-nearest neighbors.

The retina is the deepest layer of texture covering the rear of the eye, recorded by fundus images. Vessel detection and segmentation are useful in disease diagnosis. The retina's blood vessels could help diagnose maladies such as glaucoma, diabetic retinopathy, and blood pressure. A mix of supervised and unsupervised strategies exists for the detection and segmentation of blood vessels images. The tree structure of retinal blood vessels, their random area, and different thickness have caused vessel detection difficulties at machine learning calculations. Since the green band of retinal images conveys more information about the vessels, they are utilized for microscopic vessels detection. The current research proposes an administered calculation for segmentation of retinal vessels, where two upgrading stages depending on filtering and comparative histogram were applied after pre-processing and image quality improvement. At that point, statistical features of vessel tracking, maximum curvature and curvelet coefficient are extracted for each pixel. The extracted features are classified by support vector machine and the k-nearest neighbors. The morphological operators then enhance the classified image at the final stage to segment with higher accuracy. The dice coefficient is utilized for the evaluation of the proposed method. The proposed approach is concluded to be better than different strategies with a normal of 92%.

Machine learning for post-traumatic stress disorder identification utilizing resting-state functional magnetic resonance imaging.

Early detection of post-traumatic stress disorder (PTSD) is essential for proper treatment of the patients to recover from this disorder. The aligned purpose of this study was to investigate the performance deviations in regions of interest (ROI) of PTSD than the healthy brain regions, to assess interregional functional connectivity and applications of machine learning techniques to identify PTSD and healthy control using resting-state functional magnetic resonance imaging (rs-fMRI). The rs-fMRI data of 10 ROI was extracted from 14 approved PTSD subjects and 14 healthy controls. The rs-fMRI data of the selected ROI were used in ANOVA to measure performance level and Pearson's correlation to investigate the interregional functional connectivity in PTSD brains. In machine learning approaches, the logistic regression, K-nearest neighbor (KNN), support vector machine (SVM) with linear, radial basis function, and polynomial kernels were used to classify the PTSD and control subjects. The performance level in brain regions of PTSD deviated as compared to the regions in the healthy brain. In addition, significant positive or negative functional connectivity was observed among ROI in PTSD brains. The rs-fMRI data have been distributed in training, validation, and testing group for maturity, implementation of machine learning techniques. The KNN and SVM with radial basis function kernel were outperformed for classification among other methods with high accuracies (96.6%, 94.8%, 98.5%) and (93.7%, 95.2%, 99.2%) to train, validate, and test datasets, respectively. The study's findings may provide a guideline to observe performance and functional connectivity of the brain regions in PTSD and to discriminate PTSD subject using only the suggested algorithms.

Identity verification using palm print microscopic images based on median robust extended local binary pattern features and k-nearest neighbor classifier.

Automatic identity verification is one of the most critical and research-demanding areas. One of the most effective and reliable identity verification methods is using unique human biological characteristics and biometrics. Among all types of biometrics, palm print is recognized as one of the most accurate and reliable identity verification methods. However, this biometrics domain also has several critical challenges: image rotation, image displacement, change in image scaling, presence of noise in the image due to devices, region of interest (ROI) detection, or user error. For this purpose, a new method of identity verification based on median robust extended local binary pattern (MRELBP) is introduced in this study. In this system, after normalizing the images and extracting the ROI from the microscopic input image, the images enter the feature extraction step with the MRELBP algorithm. Next, these features are reduced by the dimensionality reduction step, and finally, feature vectors are classified using the k-nearest neighbor classifier. The microscopic images used in this study were selected from IITD and CASIA data sets, and the identity verification rate for these two data sets without challenge was 97.2% and 96.6%, respectively. In addition, computed detection rates have been broadly stable against changes such as salt-and-pepper noise up to 0.16, rotation up to 5°, displacement up to 6 pixels, and scale change up to 94%.

Optimizing the transfer-learning with pretrained deep convolutional neural networks for first stage breast tumor diagnosis using breast ultrasound visual images.

Female accounts for approximately 50% of the total population worldwide and many of them had breast cancer. Computer-aided diagnosis frameworks could reduce the number of needless biopsies and the workload of radiologists. This research aims to detect benign and malignant tumors automatically using breast ultrasound (BUS) images. Accordingly, two pretrained deep convolutional neural network (CNN) models were employed for transfer learning using BUS images like AlexNet and DenseNet201. A total of 697 BUS images containing benign and malignant tumors are preprocessed and performed classification tasks using the transfer learning-based CNN models. The classification accuracy of the benign and malignant tasks is completed and achieved 92.8% accuracy using the DensNet201 model. The results thus achieved compared in state of the art using benchmark data set and concluded proposed model outperforms in accuracy from first stage breast tumor diagnosis. Finally, the proposed model could help radiologists diagnose benign and malignant tumors swiftly by screening suspected patients.

Deep convolutional generative adversarial network for Alzheimer's disease classification using positron emission tomography (PET) and synthetic data augmentation.

With the evolution of deep learning technologies, computer vision-related tasks achieved tremendous success in the biomedical domain. For supervised deep learning training, we need a large number of labeled datasets. The task of achieving a large number of label dataset is a challenging. The availability of data makes it difficult to achieve and enhance an automated disease diagnosis model's performance. To synthesize data and improve the disease diagnosis model's accuracy, we proposed a novel approach for the generation of images for three different stages of Alzheimer's disease using deep convolutional generative adversarial networks. The proposed model out-perform in synthesis of brain positron emission tomography images for all three stages of Alzheimer disease. The three-stage of Alzheimer's disease is normal control, mild cognitive impairment, and Alzheimer's disease. The model performance is measured using a classification model that achieved an accuracy of 72% against synthetic images. We also experimented with quantitative measures, that is, peak signal-to-noise (PSNR) and structural similarity index measure (SSIM). We achieved average PSNR score values of 82 for AD, 72 for CN, and 73 for MCI and SSIM average score values of 25.6 for AD, 22.6 for CN, and 22.8 for MCI.

Internet of medical things embedding deep learning with data augmentation for mammogram density classification.

Females are approximately half of the total population worldwide, and most of them are victims of breast cancer (BC). Computer-aided diagnosis (CAD) frameworks can help radiologists to find breast density (BD), which further helps in BC detection precisely. This research detects BD automatically using mammogram images based on Internet of Medical Things (IoMT) supported devices. Two pretrained deep convolutional neural network models called DenseNet201 and ResNet50 were applied through a transfer learning approach. A total of 322 mammogram images containing 106 fatty, 112 dense, and 104 glandular cases were obtained from the Mammogram Image Analysis Society dataset. The pruning out irrelevant regions and enhancing target regions is performed in preprocessing. The overall classification accuracy of the BD task is performed and accomplished 90.47% through DensNet201 model. Such a framework is beneficial in identifying BD more rapidly to assist radiologists and patients without delay.