RESUMO
The aim of the present study was the investigation of the effects of mobile phones at different daily exposure times on the hippocampal expression of two apoptotic genes. Forty-eight male BALB/c mice were randomly divided into six groups with 8 animals in each group. Four experimental groups were respectively exposed to electromagnetic waves for 0.5, 1, 2 and 4 hours twice a day for 30 consecutive days. One experimental group was radiated for 4 hours once a day, while the control group did not receive any radiation during the experiment. The expression of both Bax and Bcl2 mRNAs was upregulated in the mice exposed for one and two hours. Whilst the highest expressions were observed in the two-hours radiation in the exposed group, the expression of both studied genes was downregulated in animals with longer exposure to radiation in a duration-dependent manner. The highest ratio of Bax/Bcl2 expression was observed in the mice that received radiation for four hours twice a day. These results revealed that mobile phone radiation can cause considerable changes in the balance of Bax/Bcl2 mRNA expression in laboratory mice hippocampus.
Assuntos
Telefone Celular , Regulação da Expressão Gênica/efeitos da radiação , Hipocampo/metabolismo , Hipocampo/efeitos da radiação , Proteínas Proto-Oncogênicas c-bcl-2/genética , Proteína X Associada a bcl-2/genética , Animais , Campos Eletromagnéticos/efeitos adversos , Masculino , Camundongos , Camundongos Endogâmicos BALB C , Estresse Oxidativo/efeitos da radiação , RNA Mensageiro/genética , Fatores de TempoRESUMO
BACKGROUND: The present study has investigated the effects of mobile phone (900-1800 MHz)-induced electromagnetic radiation on redox status in the heart, liver, kidney, cerebellum, and hippocampus of dams and the offspring mice. MATERIALS AND METHODS: Pregnant Balb/C were divided into two groups including the control and the experimental group. The experimental group was exposed to mobile phone (900-1800 MHz), during pregnancy (2 h/d for 20 d). The dams and the offspring of both groups were sacrificed and tissues of interest were harvested immediately after delivery. Malondialdehyde (MDA) concentration, total thiol groups (TTG) content, superoxide dismutase (SOD), and catalase (CAT) activities were determined in the tissues. RESULTS: In the experimental groups, MDA levels were significantly increased, while TTG, SOD, and CAT were significantly decreased in the total tissues of dams and their offspring. CONCLUSION: Exposure to mobile phone (900-1800 MHz) during pregnancy induced oxidative stress in tissues of dams and their offspring.
