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1.
Materials (Basel) ; 10(4)2017 Apr 22.
Artigo em Inglês | MEDLINE | ID: mdl-28772800

RESUMO

This paper describes a new silicon allotrope in the P2/m space group found by first-principles calculations using the Cambridge Serial Total Energy Package (CASTEP) plane-wave code. The examined P2/m-Si belongs to the monoclinic crystal system. P2/m-Si is an indirect band-gap semiconductor with a band gap of 1.51 eV, as determined using the HSE06 hybrid functional. The elastic constants, phonon spectra and enthalpy indicate that P2/m-Si is mechanically, dynamically, and thermodynamically stable. P2/m-Si is a low-density (2.19 g/cm³) silicon allotrope. The value of B/G is less than 1.75, which indicates that the new allotrope is brittle. It is shown that the difference in the elastic anisotropy along different orientations is greater than that in other phases. Finally, to understand the thermodynamic properties of P2/m-Si, the thermal expansion coefficient α, the Debye temperature ΘD, and the heat capacities CP and CV are also investigated in detail.

2.
Materials (Basel) ; 10(5)2017 May 22.
Artigo em Inglês | MEDLINE | ID: mdl-28772921

RESUMO

The authors would like to make the following correction to their paper[1]. In this paper,we wrongly listed the coordinates of the new silicon allotrope [...].

3.
Biotechnol Lett ; 36(8): 1711-6, 2014 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-24752814

RESUMO

Interleukin-24 (IL-24) is a novel cytokine selectively inhibiting proliferation of cancer cells but with little effect on normal cells. However, IL-24 is difficult to express in Escherichia coli. In this study, we optimised the secondary structure of the translation initiation region using computational approach to obtain non-fusion recombinant IL-24 (nrIL-24). The Gibbs free energy of the region was decreased from -22 to -9.07 kcal mol(-1), potentially promoting a loose secondary structure formation and improving the translation initiation efficiency. As a result, the expression of nrIL-24 was increased to 26 % of the total cellular protein from being barely initially detectable. nrIL-24 showed a concentration-dependent inhibition of A375 cells but had little effect on normal human cells. These results demonstrate that this method in increasing nrIL-24 expression is effective and efficient.


Assuntos
Escherichia coli/metabolismo , Expressão Gênica , Interleucinas/genética , Conformação de Ácido Nucleico , RNA Mensageiro/química , Sequência de Bases , Linhagem Celular , Cromatografia por Troca Iônica , Eletroforese em Gel de Poliacrilamida , Humanos , Interleucinas/isolamento & purificação , Interleucinas/metabolismo , Dados de Sequência Molecular , Plasmídeos/metabolismo , RNA Mensageiro/genética , Alinhamento de Sequência , Termodinâmica
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