[Research progress on circular RNA in oral squamous cell carcinoma].

Circular RNA, a non-coding RNA that forms a covalently closed continuous loop, exists widely in eukaryotic cells. The biogenesis and biological function of this type of RNA indicate that it can play a crucial role in diseases such as tumors, neural system diseases, and cardiovascular diseases; moreover, this RNA may have great potential use as a biomarker in these diseases. Oral squamous cell carcinoma (OSCC) is a common malignancy in oral surgery that is difficult to cure, metastasizes easily, and has poor prognosis. In this review, we summarize the loop-forming mechanisms and functions of circular RNA and describe the progress of current research in the development of oral cancer.

[Development of precancerous lesions of oral mucous membrane diseases and oral cancer animal models].

Precancerous lesions of oral mucous membrane diseases and oral cancer are common diseases in developing countries, especially in South Asia. However, the cancerous mechanism remains unclear, and no efficient treatment and prognosis measure are currently available. Thus, precancerous lesions of the oral mucosa and oral cancer animal models must be identified to further understand their function. In this paper, we systematically review the development of oral mucosal precancerous lesions and oral cancer animal models by referring to related research.