1.
Bioorg Med Chem Lett
; 18(6): 2147-51, 2008 Mar 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18280154
RESUMO
The pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) are a class of DNA minor groove binding agents that react covalently with guanine bases, preferably at Pu-G-Pu sites. A series of three fluorescent PBD-coumarin conjugates with different linker architectures has been synthesized to probe correlations between DNA binding affinity, cellular localization and cytotoxicity. The results show that the linker structure plays a critical role for all three parameters.