A Greater Platelet Dose May Yield Better Clinical Outcomes for Platelet-Rich Plasma in the Treatment of Knee Osteoarthritis: A Systematic Review.

PURPOSE: To determine whether the platelet dose administered during a platelet-rich plasma (PRP) injection for knee osteoarthritis (OA) affects clinical outcomes. METHODS: A systematic review was performed by searching PubMed, Cochrane Library, and Embase for randomized controlled trials with at least 1 study arm using PRP for knee OA. Only studies that provided a platelet count, concentration, or dose with a minimum of 6-month outcome scores were included. Studies in which the PRP group had statistically significant positive outcomes were separated from those without statistical significance. The average platelet doses for studies with positive outcomes in the PRP group were compared with those without positive outcomes. RESULTS: After exclusion criteria were applied, 29 studies were analyzed. Of the 29, there were 31 arms that used PRP as a treatment method, of which 28 had statistically significant positive outcomes at 6 months compared with the control group. The mean platelet dose in the 28 with a positive outcome was 5,500 ± 474 × 106, whereas the 3 that had no positive difference had a mean platelet dose of 2,302 ± 437 × 106 (P < .01). There were 18 studies with 12-month outcomes, with 16 of 18 having positive outcomes. The positive studies had an average platelet dose of 5,464 ± 511, whereas the studies that had no statistical difference had an average platelet dose of 2,253 ± 753 × 106 (P < .05). CONCLUSIONS: Improved clinical outcomes from PRP injections for knee OA may be related to a greater platelet dose. LEVEL OF EVIDENCE: Level II, systematic review of Level I and II studies.

Exercise-Associated Hyponatremia in a Lactating Female.

A 37-year-old woman presented to the emergency department with severe headache, which quickly progressed to altered mental status and seizure activity in hospital. Her initial serum sodium concentration ([Na]) was 126 mmol/L. In the 24 hours before admission, she exercised vigorously for 120 minutes (interval training plus yoga) and also consumed more than 4 liters of fluid during that time to both stay hydrated and facilitate milk production because she was actively nursing 2 children. Her serum [Na] and altered mental status corrected slowly over the next 48 hours with furosemide, hypertonic saline, and fluid restriction. This case is unique because it discusses the possible pathogenic role that lactation-induced oxytocin release may have on sustained antidiuresis and dilutional exercise-associated hyponatremia (EAH). This would be the first report documenting EAH in a lactating woman, which may highlight an underrecognized risk factor for physically active women who are concurrently breast-feeding.

Single leg squat test and its relationship to dynamic knee valgus and injury risk screening.

BACKGROUND: Lower extremity injuries are common in athletes. Valid tests to assess for risk of injury that are easily performed during a preparticipation sports physical examination are lacking. Two-dimensional (2D) analysis of the drop-jump test can identify athletes at risk, but it is too expensive and cumbersome to use in this setting. OBJECTIVE: To identify if those who perform a "positive"(abnormal postures) single leg squat (SLS) test also exhibit greater "dynamic valgus" on the 2D drop-jump test. Our secondary purpose was to assess whether group differences in gender, age, or body mass index are evident between those who exhibit a positive SLS test result versus a negative SLS test result. Also, we wanted to determine any gender differences with the 2D drop-jump test. DESIGN: A cross-sectional study. SETTING: Private practice, preparticipation sports physical examinations. PARTICIPANTS: A total of 142 middle school and high school athletes. METHODS: Participants performed a SLS test and a drop-jump test during their preparticipation sports physical examination. Individuals were partitioned into groups based on the outcome of their SLS test (positive SLS group versus negative SLS group). Independent sample t-tests were used to evaluate SLS group differences in the drop-jump test, age, and body mass index, and the χ(2) test was used to evaluate SLS group differences in gender (P ≤ .05). MAIN OUTCOME MEASUREMENTS: The SLS test and drop-jump test. RESULTS: Seventy-three of the 142 athletes (51%) had a positive SLS test result, whereas 69 athletes (49%) had a negative SLS test result. Individuals in the positive SLS group had a significantly lower knee-hip ratio), indicative of greater dynamic knee valgus, than did those in the negative SLS group (P = .02). Individual characteristics between SLS groups including gender, age, and body mass index were similar. CONCLUSION: The SLS test is a reasonable tool to use in preparticipation sports physical examinations to assess for dynamic knee valgus and the potential risk of lower extremity injury.