[Ecological immunodeficiency: immunogenetic aspects of its etiology and correction]. / Ekologicheskii immunodefitsit: immunogeneticheskie aspekty ego razvitiia i korektsii.

The examinations of auto-transport Kazakh drivers have indicated that there is a significant reduction in some immunological parameters HLA-B5 and HLA-DR5-proliferative responses of lymphocytes to mitogens, production of interleukin-1 and interleukin-2, activity of NK and LAK-cells. It is suggested that these impairments occur with their long-term exposure to automobile transport effluents (ATE), since the same changes in immunological parameters were found previously in the experiments with animals exposed to ATE for a long time. Some of the detected immunoresponsive disorders are associated with the availability of definite HLA antigens, such as HLA-B5 and HLA-P5. The new immunomodulating agents thymohexin (TH) and phyto-extraction drugs C4 and C6 used in vitro substantially restored the lower functional activity of immunocompetent cells and production of cytokines (thymohexin was particularly effective). The most marked recovery was observed in the drivers with the phenotype HLA-B6+ and HLA-P5+, i.e. in persons with maximally ATE-reduced immunological parameters.

[Rate of development of immunologic memory and features of the secondary immune response in mice of high and low-reacting strains]. / Skorost' razvitiia immunologischeskoi pamiati i osobennosti vtorichnoi immunnoi reaktsii u myshei vysoko- i nizkoreagiruiushchikh linii.

Immunological memory to sheep red blood cells developed in mice of strain CBA, DBA/2, and hybrids (CBAXXC57BL/6) F1 24 hours after the administration of a low dose of the antigen, and in C57BL/6 mice -- in 48 hours. The level of the secondary immune response in CBA, C57BL/6, and hybrid F1 mice was much greater than in the DBA/2 mice. The maximal production of the antibody-forming cells in the spleen of CBA mice occurred after twofold administration of low antigen doses. In contrast to this, repeated administration of a high antigen dose is required to obtain a marked immune response in adoptive transfer of spleen cells of the C57BL/6 strain.

[Influence of several factors on the formation of immunologic memory]. / Vliianie nekoterykh faktorov na formirovanie immunologicheskoi pamiati.

Experiments were conducted on mice with the use of sheep erythrocytes as an antigen; the level of the secondary immune response of the spleen (in situ) cells or in adoptive transfer was in reverse relationship to the dose of erythrocytes used for primary immunization. Cyclophosphamide administered to the animals together with the antigen proved to stimulate the immune reaction of mice to the repeated erythrocyte administration; this occurred only in case of using comparatively high antigen doses for the priming. The mechanisms of the phenomenon described are discussed.