Lesion Distribution in the Metacarpophalangeal and Metatarsophalangeal Region of 341 Horses Using Standing Magnetic Resonance Imaging.

Pain localised to the metacarpophalangeal (MCP) and metatarsophalangeal (MTP) region represents a frequent cause of lameness in sport horses, and standing magnetic resonance imaging (MRI) of these regions is increasingly being acquired. This multicentre retrospective study describes the ranges of abnormalities identified on standing MRI of the MCP/MTP region and compares patterns of abnormalities between forelimbs, hindlimbs and different sports disciplines. In total, 341 MRI reports were reviewed. Subchondral bone plate irregularities, condylar and proximal phalanx pathologies were frequently identified with subchondral bone defect, sclerosis and increased intensity on STIR images often described. Medial pathology was frequently identified in the forelimbs, and more lateral pathology was reported in the hindlimbs, which could potentially reflect differences in the loading patterns. Significant differences in MRI findings were found between different sports activities, with MCP/MTP bone pathology occurring more frequently in MRI reports from race and endurance horses and MCP/MTP soft tissue injuries being reported more frequently in dressage and show-jumping horses, particularly in the suspensory apparatus, including the distal sesamoidean ligaments. The findings of this study identify patterns of MCP/MTP abnormalities detected using standing MRI, with differences seen between forelimbs and hindlimbs and between different sports disciplines.

Magnetic Resonance Imaging Findings in the Proximal Metacarpal Region of 359 Horses and Proximal Metatarsal Region of 64 Horses Acquired Under Standing Sedation.

Standing magnetic resonance (MR) images of proximal metacarpal/metatarsal regions are increasingly being acquired. This study aimed at describing ranges of abnormalities detected in sport/racehorses, using retrospective evaluation of magnetic resonance imaging (MRI) reports from horses with lameness isolated to proximal metacarpal/metatarsal regions with images acquired standing. It was hypothesized that MRI features are different between metacarpal and metatarsal regions and between horses doing different sports. Reports from 359 forelimbs and 64 hindlimbs were included. Palmar/plantar metacarpal/metatarsal bone injury and suspensory desmopathy, which often occurred concurrently, were most frequently reported. Third metacarpal abnormalities were more likely at palmar/medial locations, including cortical (86.4%) and trabecular (38.2%) pathology with frequent thickening, irregularity, and periosteal/endosteal abnormalities. Fluid signal was reported in cortical (38.7%) and trabecular (22.6%) bone. Medial intermetacarpal articulation abnormalities were more frequently reported (52.5%) than lateral. Suspensory ligament pathology was reported in 83.8% forelimbs, frequently with cortical (74.1%) or trabecular (32.9%) pathology. Tarsal-joint abnormalities were significantly more likely than carpal-joint abnormalities. Third metatarsal cortical (57.8%) and trabecular (20.3%) pathology was most frequently plantar, but significantly more likely to be dorsal than forelimbs. Metatarsal fluid signal was significantly less likely than metacarpal. Lateral intermetatarsal articulation pathology (23.4%) was more frequent than medial; medial was significantly more likely in forelimbs. Suspensory ligament abnormalities were reported in 64.1% hindlimbs, 39.1% having concurrent cortical pathology. Metacarpal fluid signal was significantly more likely in endurance/racehorses than dressage/show jumping horses. Dressage was overrepresented in hindlimb suspensory origin pathology. These findings indicate different pathology patterns between forelimb/hindlimb and between different sports and may be useful for MRI interpretation.

Acute exercise does not induce an acute phase response (APR) in Standardbred trotters.

The purpose of the study was to investigate whether acute strenuous exercise (1600- to 2500-m race) would elicit an acute phase response (APR) in Standardbred trotters. Blood levels of several inflammatory markers [serum amyloid A (SAA), haptoglobin, fibrinogen, white blood cell count (WBC), and iron], muscle enzymes [creatinine kinase (CK) and aspartate transaminase (AST)], and hemoglobin were assessed in 58 Standardbred trotters before and after racing. Hemoglobin levels increased and iron levels decreased 12 to 14 h after racing and haptoglobin concentrations, white blood cell counts, and iron levels were decreased 2 and/or 7 d after racing. Concentrations of CK, AST, SAA, and fibrinogen were unaltered in response to racing. Acute strenuous exercise did not elicit an acute phase reaction. The observed acute increase in hemoglobin levels and decreases in haptoglobin and iron levels may have been caused by exercise-induced hemolysis, which indicates that horses might experience a condition similar to athlete's anemia in humans. The pathogenesis and clinical implications of the hematological and blood-biochemical changes elicited by acute exercise in Standardbred trotters in the present study warrant further investigation.

L'objectif de la présente étude est d'investiguer l'effet de l'exercice intensif (1600­2500 m) sur l'apparition d'une phase inflammatoire aigué chez des trotteurs. Les taux sanguins de différents marqueurs inflammatoires [serum amyloid A (SAA), haptoglobine, fibrinogène, globules blanc (WBC) et fer], d'enzymes musculaires [creatinine kinase (CK) et aspartate transaminase (AST)] et d'hémoglobine ont été évalué dans 58 trotteurs avant et après la course. Respectivement une augmentation et diminution des taux d'hémoglobine et de fer furent présente 12­14 heures suivant la course. Une réduction des taux d'haptoglobine, de globules blanc et de fer était présente 2 et/ou 7 jours après la course. Aucun changement dans les concentrations de CK, AST, SAA et fibrinogène n'a pu être démontre en relation avec la course.L'exercice intense réalise lors de cette étude n'a pu induire de phase inflammatoire aigué. L'augmentation d'hémoglobine et la diminution d'haptoglobine et de fer peuvent être causées par une hémolyse induite par l'exercice, indiquant qu'une condition similaire à l'anémie de l'athlète chez l'homme existe chez le cheval. La pathogénèse et l'implication clinique des modifications hématologiques et biochimiques lié à un exercice intense chez les trotteurs dans la présente étude justifié de plus amples investigations.(Traduit par Docteur Denis Verwilghen).