1.
Bioorg Med Chem Lett
; 13(20): 3593-6, 2003 Oct 20.
Artigo
em Inglês
| MEDLINE
| ID: mdl-14505677
RESUMO
A series of 2-heteroaryl-4-arylimidazoles with potent in vitro activity at the NPY5 receptor was developed. Introduction of electron-withdrawing groups on the 4-aryl ring led to a significant improvement of in vitro potency. Several analogues from this series had anorectic activity in rodent feeding models, but were also found to have undesired behavioral effects in spontaneous locomotor activity.