1.
2.
Ann Pharm Fr
; 75(6): 455-462, 2017 Nov.
Artigo
em Francês
| MEDLINE
| ID: mdl-28619467
RESUMO
The synthesis and the study of the binding affinity to human receptors of glucocorticoids, mineralcorticoids, androgens, estrogens and progesterone of 3-phenoxy-4-hydroxycoumarins and 3-phenoxy-4-phenylcoumarins were performed. It shows the absence of any binding affinity of all these derivatives to glucocorticoid and mineralcorticoid receptors and a non-selective binding affinity to androgen, oestrogen and progesterone receptors with 3-phenoxy-4-phényl-coumarins.
Assuntos
4-Hidroxicumarinas/síntese química , 4-Hidroxicumarinas/farmacologia , Cumarínicos/síntese química , Cumarínicos/farmacologia , Receptores de Esteroides/efeitos dos fármacos , Ligação Competitiva/efeitos dos fármacos , Hormônios/metabolismo , Humanos , Especificidade por Substrato
3.
Ann Pharm Fr
; 57(3): 251-4, 1999 May.
Artigo
em Francês
| MEDLINE
| ID: mdl-10427861
RESUMO
The study of the relationships between the structure and the free radical scavenging activity of substituted 4-hydroxycoumarine derivatives, indicates the favorable effect of electron donating substituents.