[Signs of microbial sensibilization in patients with various cardiovascular diseases].

AIM: Analysis of intensity of non-specific (level of sera cytokines) and specific (titers of antibodies against Chlamydophila pneumoniae) factors of humoral immunity in patients with arterial hypertension and various forms of ischemic heart diseases. MATERIALS AND METHODS: 282 individuals were the object of examination--157 (55.7%) males. 8 groups were formed, comparable by age: 1 - 32 individuals with exertional angina pectoris of the III functional class; 2 - 20 individuals with healing Q-positive myocardial infarction (MI); 3 - 15 individuals with Q-negative healing MI; 4 - 15 individuals with unstable angina pectoris; 5 - 40 individuals with persisting atrium fibrillation; 6 - 35 individuals with clinically significant chronic heart failure; 7 - 92 patients with hypertension of the II stage; 33 conditionally healthy composed the control group. Class A and G immunoglobulins against C. pneumoniae, IL-1ß, -6, -17, TNFα content in blood were determined. RESULTS: The proportion of seropositive individuals in groups with IgG and IgA titer characteristics was determined. Data on the level of cytokines, taking into the account seropositivity, and titer increase are presented. Correlations between hemostasis system were established, that demonstrate increase of thrombophilia in the presence of persistent infection, mediated via induction of cytokine production. Significant differences by instrumental parameters depending on seropositivity were not obtained. CONCLUSION: Contribution of microbial sensibilization and latent inflammation in the development and destabilization of atherogenesis-associated diseases seems evident.

[Mechanisms of the effect of exogenous thyroxine on the regulation of the immune response in mice]. / Nekotorye mekhanizmy vliianiia ékzogennogo tiroksina na reguliatsiiu immunnogo otveta u myshei.

The influence of repeated administration of thyroxin (T4) in doses of 4 or 4000 micrograms/100 g body weight daily upon T-B co-operation and specific T-suppressor formation was studied on CBA male rats. A stimulating effect of T4 low doses on the lymph node T-cell ability was demonstrated to co-operate with the normal marrow B-cells over a process of generation of the humoral response to the sheep red blood cells within the system of singeneic transfer. The injection of various T4 doses to donors of the marrow B-lymphocytes or recipients of T- and B-cells from control animals did not alter the immune response in recipients. The inhibiting T4 effect on the formation of cell-suppressors of the antibody response to the sheep red blood cells, depending on the dose of hormone injected, was established. It is suggested that thyroid hormones are capable of regulating the immune response to thymus-dependent antigens through a selective action on regulatory T-lymphocytes.