[Biological age, adrenoreception and lipid peroxidation in patients with ischemic heart disease]. / Biologicheskii vozrast, adrenoretseptsiia i perekisnoe okislenie lipidov u bol'nykh ishemicheskoi bolezn'iu serdtsa.

The article deals with electro-kinetic potential of cellular nucleus considered as an indicator of unspecific reactivity and presents some data on molecular and cellular mechanisms of adreno- and muscarino-receptive interactions, such as adrenalin, noradrenaline and DOPA blood levels, lipid peroxidation, erythrocyte resistance to peroxidation. The attempt is made to comprehend directions and trends of aforementioned processes in patients with stable and unstable stenocardia as well as in myocardial infarction with regard to sex and influence of central M-cholinoblockader amizyl. The drug provides adaptive effect, corrects affected adreno-reception, protects biomembranes from lesion, promotes their "fluidity" and reduces rigidity.

[The molecular cellular aspects in predicting the course of an acute myocardial infarct]. / Molekuliano-kletochnye aspekty prognozirovaniia techeniia ostrogo infarkta miokarda.

Ultra-high-frequency dielectrometry was used to determine the dielectric permeability of erythrocyte suspension cell membranes in 48 patients with acute myocardial infarction who were given agonists, antagonists, and modulators of the adenylate cyclase system. The study showed that the functional status of erythrocyte membranes changed correlating with the clinical course of the disease. Changes in this status were followed by complications of improvement. It was evidenced that the trend of a pathological process in coronary stress was associated with the functional status of erythrocyte membranes. Ultra-high-frequency dielectrometry is a sensitive method for evaluating the status of patients with myocardial infarction, controls the natural history of the diseases at the molecular level and to predict the development of complications.

[Molecular mechanisms of the development of cardiovascular pathology]. / O molekuliarnykh mekhanizmakh razvitiia serdechno-sosudistoi patologii.

Changes of a number of functions of beta-receptor complex mechanism have been analyzed by means of the microwave-dielectrometry method on native erythrocytes at various stages of cardiovascular pathology. The control scheme of beta-receptor complex has been analyzed in the adenylate cyclase system and the regions have been extracted which are subjected to an attack of pathological factors of the effect.

[UHF-dielectrometry in the study of parameters of native adenylate cyclase complex during modulation of its activity]. / Issledovanie metodom SVCh-diélektrometrii parametrov nativnogo adenilattsiklaznogo kompleksa pri moduliatsii ego aktivnosti.

Some features of molecular mechanisms of adenylate-cyclase system of native human erythrocytes were studied by the UHF-dielectrometry method. The results obtained show great changes in cell structure hydration when there is some influence on the membrane protein components which are involved in transmembrane signal transformation. The observed effects permit definite conclusions to be drawn concerning some molecular mechanisms of cell regulation. The obtained data demonstrated the following: the key role of N-protein, spatial separation of PGE2 regulatory centres and hormones on the beta-receptor, system modulation by the change of Ca2+ ions concentration in the presence of PGE2 and the connection of the alpha-receptor with the calcium slow channel.

[Activity of microsomal oxidation and biochemical characteristics of the sympathico-adrenal system in myocardial ischemia in rats]. / Aktivnost' mikrosomal'nogo okisleniia i biokhimicheskie osobennosti simpatiko-adrenalovykh vliianii pri ishemii miokarda u krys.

Overloading of cardiomyocytes with calcium, developed after administration of catecholamines, led to activation of lipid peroxidation in plasmatic membranes, which might cause the myocardium destruction. Alteration of the monoamine oxidase activity appears to be of importance in myocardium impairment.

[The individual choice of drug preparations]. / K voprosu ob individual'nom podbore lekarstvennykh preparatov.

A method of superhigh-frequency dielectric measurement was proposed for control of hormone-stimulated adenylate cyclase system of human erythrocytes. The method was used for the analysis of some adrenoblockers. Differences in their effects in healthy persons and patients with cardiovascular pathology were found.

[Hydration--a parameter responding to the functional changes in membranes]. / Gidratatsiia--parametr, otvechaiushchii na funktsional'nye izmeneniia membran.

The paper presents the possibilities of the UHF-dielectrometry method in investigation of molecular mechanisms of membrane functioning.