[Creation of phytovaleologic drugs].

This is a new field of knowledge in medical sciences that means "Healthy Way of Life". Based on the data of medical plants and on the results of Phytochemical and Pharmacological studies, carried out in preliminary experiments, there are cultivated compositions of Valeological substances, potentially having radio protective activity. As the basis for the selection of raw materials and their correlation in mixture, there were taken the data of spontaneous analysis of chemical composition having pharmacological (radio protective) activity of various compositions. As the result, the types of studied raw materials and their parties by weight in total mixture have been defined: Valeological substances 1: 1. Tea (leaves); 2. Common plantain (leaves); 3. Horse gowan (flowers); 4. Blackberry (leaves) 5. Hips; 6. Peppermint (leaves). Valeological substances 2: 1. Tea (leaves); 2. Dandelion (leaves); 3. Horse gowan (flowers); 4. Knotgrass (herbage); 5. Hips; 6. Peppermint (leaves) Experimental studies revealed that the most optimal way of brewing tea is rational method. Valeological substances 1 and 2 (tea with radio protective activity) "Protector" and "Adjara" - correspondingly. Technical conditions and technological instructions for radio protective tea "Protector" and "Adjara" are created. Pharmacological studies of tea "Protector" and "Adjara" have taken place in the Branch of Biological University of Buryatia (Academy of Science of Russian Federation) under the supervision of Prof. S. M. Nikolaev. Radio protective teas "Protector" and "Adjara" is approved by the Ministry of Health Sciences.

[Radio protective drug production from fresh leaves of Aloe arborescens Mill].

Nowadays, phytogenous drugs are wildly used as radio protective substances. The aim of the research was to study radio protective characteristics of aloe juice fraction and to develop new technology for radio protective drug production. Technological scheme for getting the drug in two stages. The first stage - extraction of juice from fresh leaves; the second stage - extracting bagasse have been developed and optimal environment for bagasse extraction are defined: Infusion of bagasse with 96 % ethyl spirit (1:1) during 30 minutes, continuation of extracting with water on correlation to raw materials 10:1 at temperature of 70 degrees C during 30 minutes. For the basis of the first series of balanced loading there are taken the optimal parameters of extracting process, on the basis of which in its turn was developed technological scheme of getting dry extract of aloe. Dry extract is a fine-dispersed reddish-yellow (brownish-yellow) powder, which can be easily dissolved in warm (40-60 degrees C) water. Pharmacological researches were conducted in the Institute of General and Experimental Biology, Siberian Branch, Russian. Academy of Sciences. The remarkable radio protective effect of the drug was revealed.

[The modulatory influence of moxonidine on the different link of sympatho-adrenal system and hemodynamic reactions in normo and hypertensive rats during emotional stress].

Effect of moxonidine on hemodynamic parameters, baroreflex sensitivity (BS) and sympatho-adrenal system was studied on the model of emotional stress in normotensive (N) and hypertensive (H) rats. Moxonidine was administered intravenously in daily dose 100 mcg/kg during one week prior to stress condition. It was shown that moxonidine reduced pressor reactions of arterial pressure, tachycardia and have increased BS especially in H animals, which was blunted during aversive stimulation. Moxonidine also revealed the effect of pharmacological correction of catecholamine - norepinephrine and epinephrine content in the myocardium and adrenals in stress and post stress period more markedly in H rats. The data obtained indicate the preventive antistress activity of the moxonidine.