RESUMO
Blockade of α6, α3ß2, α9α10, and α7 subtypes of nicotinic acetylcholine receptors slows tumor growth in vivo, increases cytotoxic activity of splenocytes from tumor-bearing mice, and, to some extent, reduces the viability of Ehrlich carcinoma cells in vitro. These data indicate that nicotinic acetylcholine receptors are involved in oncogenesis, affecting the survival of tumor cells, inter alia, via modulation of the antitumor immunity.
Assuntos
Antineoplásicos/farmacologia , Carcinoma de Ehrlich/metabolismo , Antagonistas Nicotínicos/farmacologia , Baço/citologia , Animais , Antineoplásicos/química , Carcinogênese , Proliferação de Células , Sobrevivência Celular , Conotoxinas/metabolismo , Camundongos , Transplante de Neoplasias , Antagonistas Nicotínicos/química , Receptores Nicotínicos/metabolismo , Receptor Nicotínico de Acetilcolina alfa7/antagonistas & inibidoresRESUMO
The literature data on glycine metabolism in neural tissue, mitochondrial Gly-cleaving system, Gly-catching system in neural and glial cells are summarized. The peculiarities of localization and distribution of specific glycine receptors and binding-sites in nervous tissue of mammals are described. Four types of glycine-binding receptors are described: own specific glycine receptor (Gly-R), ionotropic receptor, which binds N-methyl-D-aspartate selectively (NMDA-R), and ionotropic receptors of g-aminobutyrate (GABA A -R, GABA С -R). The features of glycine effects in neuroglial cultures are discussed.
