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1.
J Pediatr Surg ; 55(3): 425-432, 2020 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-31128845

RESUMO

INTRODUCTION: Fashioning a patent, watertight anastomosis in patients with esophageal atresia is a challenging task in pediatric surgery, particularly when performed under tension. A reproducible suture-less alternative would decrease operative time. We evaluated magnetic esophageal compression anastomoses in a novel bypass-loop swine model. METHODS: Eight-week-old piglets underwent thoracotomy to mobilize the esophagus at the carina to create a U-shaped loop. Custom-made 8 mm diameter Neodymium Magnets were inserted into the esophagus proximal and distal to the loop, then mated side-to-side at the future anastomosis site. Pigs were observed for 8 (n = 4), 10 (n = 6), and 12 (n = 2) days and then sacrificed. The magnetic compression anastomosis was evaluated macroscopically, by radiography, burst pressure testing, and histology. RESULTS: All 12 pigs survived until the endpoint. Separation of the magnets occurred at a median of 9 days. Contrast esophagrams showed patency and no leak. All anastomoses withstood pressures well over 13 kPa without leak. Histopathology showed epithelialized circular scar tissue. CONCLUSION: Magnetic compression anastomoses of the esophagus using our specially-designed magnets are formed between the 8th and 10th postoperative day, are patent and mechanically resistant to supraphysiologic intraluminal pressures. These data lay the basis for a potential clinical application in patients born with esophageal atresia. LEVEL OF EVIDENCE: Not applicable (experimental animal study).


Assuntos
Anastomose Cirúrgica , Atresia Esofágica/cirurgia , Imãs , Anastomose Cirúrgica/instrumentação , Anastomose Cirúrgica/métodos , Animais , Modelos Animais de Doenças , Esôfago/cirurgia , Feminino , Gravidez , Suínos
2.
J Laparoendosc Adv Surg Tech A ; 29(6): 852-855, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-30882275

RESUMO

Introduction: Thoracoscopic esophageal atresia repair has become increasingly popular, but is still limited to a few expert centers and has some challenges and shortcomings. One of them has a longer operation time compared with conventional thoracotomy. Magnetic compression anastomosis may contribute toward shorter operation times by avoiding the time-consuming anastomotic suturing. We aimed to establish a method of testing sutureless anastomoses in parallel to having swine eating the natural way. Materials and Methods: We used four juvenile Pietrain swine-aged 8 weeks, weighing 15 kg-to establish a living animal model after preceding cadaver tests. Esophagi were fully mobilized through right-sided thoracotomy to gain sufficient length to create an esophageal loop that served as a bypass for food after magnet deployment. Six hours later, patency of the bypass esophageal loop was assessed by passing an orogastric tube and by allowing swine to drink methylene blue-stained water. We also tested the device stability using the classical burst pressure test. Results: The esophageal lumen was patent for feeding tube. Swine were able to drink and methylene blue colored fluid reached the stomach. Clinical signs of obstruction such as regurgitation or coughing were absent. Magnets sustained burst pressures up to 200,000 Pascal until they became disrupted. At 6 hours after magnet placing, we already saw subtle esophageal mucosa erosions indicating the beginning of anastomotic formation. Conclusion: This animal model is useful to test different magnet designs for sutureless esophageal anastomosis or even future devices for in vivo tissue engineering.


Assuntos
Procedimentos Cirúrgicos do Sistema Digestório/métodos , Modelos Animais de Doenças , Nutrição Enteral/métodos , Atresia Esofágica/cirurgia , Esôfago/cirurgia , Imãs , Suínos/cirurgia , Anastomose Cirúrgica/instrumentação , Anastomose Cirúrgica/métodos , Animais , Procedimentos Cirúrgicos do Sistema Digestório/instrumentação , Humanos , Duração da Cirurgia , Avaliação de Resultados em Cuidados de Saúde
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