RESUMO
Although 10% to 15% of gastro-oesophageal reflex disease (GERD) patients have Barrett's oesophagus, neither the frequency nor the severity of symptoms correlates with the presence of Barrett's epithelium. Age, male sex, white race, and obesity have been implicated in some studies. The studies in Indian population reflect low prevalence rates; however, there is no study of obesity as independent risk factor for Barrett's disease in Indian population. The present study showed Barrett's oesophagus in 9.5% patients who were obese as compared to non-obese patients having Barrett's 6.7% suggesting obesity might not predispose to Barrett's oesophagus, in patients of GERD taken criterion for obesity as BMI more than 30.
Assuntos
Esôfago de Barrett/epidemiologia , Refluxo Gastroesofágico/epidemiologia , Idoso , Idoso de 80 Anos ou mais , Esôfago de Barrett/patologia , Humanos , Índia/epidemiologia , Masculino , Metaplasia , Pessoa de Meia-Idade , Obesidade/epidemiologiaRESUMO
Three siblings from consanguineous parents, originating from Tanzania, presented with symptoms of complete or partial agenesis of the corpus callosum. Two males had in addition a sensorimotor neuropathy, moderate mental retardation and skeletal dysmorphism (Andermann syndrome). A study of sural nerve biopsies revealed thickening of the perineurium and reduction in the number of large myelinated fibres with axonal degeneration. Muscle biopsies showed neurogenic atrophy. The Andermann syndrome is autosomal recessive and almost exclusively confined to the region of Charlevoix and Saguenay-Lac-St-Jean (Quebec, Canada). Moreover in families with the Andermann syndrome, no siblings with only agenesis of the corpus callosum have been described.
Assuntos
Agenesia do Corpo Caloso , Neuropatia Hereditária Motora e Sensorial/genética , Adolescente , Axônios/patologia , Biópsia , Encéfalo/patologia , Criança , Aberrações Cromossômicas/genética , Transtornos Cromossômicos , Consanguinidade , Corpo Caloso/patologia , Feminino , Genes Recessivos/genética , Neuropatia Hereditária Motora e Sensorial/diagnóstico , Neuropatia Hereditária Motora e Sensorial/patologia , Humanos , Deficiência Intelectual/diagnóstico , Deficiência Intelectual/genética , Deficiência Intelectual/patologia , Masculino , Fibras Nervosas Mielinizadas/patologia , Nervo Sural/patologia , Síndrome , Tanzânia , Tomografia Computadorizada por Raios XRESUMO
The pattern of malignant lymphoma (ML) in the Middle East has not been well documented and constitutes a lacuna in the epidemiology of this disease. This preliminary report describes a retrospective study of 46 native Omanis who, at the Sultan Qaboos University Hospital and the Royal Hospital, Sultanate of Oman, were diagnosed in 1990 as having ML. Of the 46 patients with ML, 16 (35%) were found to have Hodgkin's disease (HD) and 30 (65%) had non-Hodgkin's lymphomas (NHL). Among the HD, mixed cellularity (MC) appeared in 9 cases (56%). Among the NHL, 25 (83%) showed a diffuse pattern and 5 (17%) were follicular. Twenty-one (70%) of the NHL were of high-grade type, of which 5 (17%) were Burkitt-like lymphomas. Immunological study of the NHL biopsies revealed 24 (80%) of the B cell type, 2 (7%) of the T-cell type, 1 (3%) of the null cell type and 3 (10%) could not be classified because of scanty material or unsatisfactory fixation. We present in this study the pattern of ML in Oman, which was found to be different from those reported from the West, Far East and Saudi Arabia, with some resemblance to the pattern from tropical Africa.
