1.
Org Lett
; 24(8): 1647-1651, 2022 03 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35175781
RESUMO
The highly enantioselective aza-Michael reaction of tert-butyl ß-naphthylmethoxycarbamate to cyclic enones has been accomplished by using a new cinchona alkaloid derived C(9)-urea ammonium catalyst under phase-transfer catalysis conditions with up to 98% ee at 0 °C. The resulting aza-Michael adducts can be converted to versatile intermediates by selective deprotection and the cyclic 1,3-aminoalcohols by diastereoselective reduction with up to 32:1, which have been widely used as important pharmacophores in pharmaceutical development.