RESUMO
The crystal structure of the title compound, C(32)H(24)O(4), contains three fused dihydropyran rings (A, B and C); ring A is fused with a benzene ring while the other two rings, B and C, are fused with naphthalene rings. Ring A adopts a half-chair conformation with an equatorial methoxy group, whereas ring B assumes a distorted half-chair conformation, the A/B ring junction being trans. Ring C adopts a distorted half-boat conformation and is nearly orthogonal to ring B. Ring C is inclined to the best plane of ring A at an angle of 112.1 (1) degrees.
Assuntos
Inibidores de Integrase de HIV/química , Compostos Heterocíclicos de 4 ou mais Anéis/química , Cristalografia por Raios X , Ligação de Hidrogênio , Estrutura MolecularRESUMO
Acute (after 4 hr) and short-term (after 7 days) effects of ingesting heated and unheated groundnut, coconut and safflower oils on plasma lipids, lipoproteins and postheparin lipopolytic activity (PHLA) were studied in rats. All heated oils were characterized by increases in carbonyl value, peroxide value and free fatty acid (FFA) content, except heated coconut oil which showed a decrease in FFA content. Heating procedure also did not alter to an appreciable extent their fatty acid compositions. Acute and short-term effects of feeding heated and unheated oils showed no significant differences in rat plasma levels of total cholesterol (TC), total triglycerides, total phospholipids, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol + very-low-density lipoprotein cholesterol, TC/HDL-C ratio and PHLA. Inspite of certain changes in some of the indices of thermal alteration of these heated oils, consumption of such heated oils by rats did not have any significant effect on various plasma parameters in these animals.
