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1.
Drug Discov Today ; 28(7): 103601, 2023 07.
Artigo em Inglês | MEDLINE | ID: mdl-37119964

RESUMO

This report discusses potential therapies for treating human coronaviruses (HCoVs) and their economic impact. Specifically, we explore therapeutics that can support the body's immune response, including immunoglobulin (Ig)A, IgG and T-cell responses, to inhibit the viral replication cycle and improve respiratory function. We hypothesize that carbon quantum dots conjugated with S-nitroso-N-acetylpenicillamine (SNAP) could be a synergistic alternative cure for treating respiratory injuries caused by HCoV infections. To achieve this, we propose developing aerosol sprays containing SNAP moieties that release nitric oxide and are conjugated onto promising nanostructured materials. These sprays could combat HCoVs by inhibiting viral replication and improving respiratory function. Furthermore, they could potentially provide other benefits, such as providing novel possibilities for nasal vaccines in the future.


Assuntos
Óxido Nítrico , Replicação Viral , Humanos , S-Nitroso-N-Acetilpenicilamina/farmacologia
2.
Waste Manag Res ; 41(6): 1063-1080, 2023 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-36644994

RESUMO

With the burning issue of air, land and water pollution, the premonition of looking forward towards a future devoid of any kind of oil and gas reserves has caused a paradigm shift towards recycling, recovery of any synthetic polymer and also to dispose them off environmentally. Among them are plastics such as polyethylene terephthalate and poly vinyl chloride. Polyurethane (PU) is also under the scanner to dispose of or recycle it environmentally and sustainably. PU is at present the sixth most utilized polymer all over the world with a production of nearly 18 million tonnes per annum, which roughly estimates a daily production of PU products of greater than a million of cubic metres. Its thermostable nature is one of the major reasons for its higher preference over other polymers. This review article discusses the current disposal and technologies available to recycle waste PU foams and also sheds some light on some additional work being done in the field to upgrade the existing technology. Interestingly, some methods mentioned here are probably undergoing scale-up trials runs by now. Currently, the most researched and studied ones are mechanical recycling and glycolysis. But microbial and enzymatic disposal methods can be turned into full-scale industrial recycling processes in the near future. Additionally, we can see an archetypal shift from traditional oil-based sources to the agrarian sources.


Assuntos
Poliuretanos , Gerenciamento de Resíduos , Plásticos , Polímeros , Reciclagem/métodos
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