[In vitro studies of the effect of a mistletoe preparation on melanoma cells]. / In Vitro Untersuchungen zur Wirkung eines Mistelpräparats auf Melanomzellen.

In concentrations usually achieved in vivo, extracts of mistletoe (e.g. Iscador) exert no direct action on melanoma cells or human fibroblasts in tissue cultures. Only very high concentrations of Iscador in combination with prolonged incubation time (over several days) resulted in damaging the cells irreversibly. Therefore we are not able to confirm the suggestion that mistletoe extracts exert a deleterious action selectively on malignant cells.

[Understanding microcapillary angioma, observations in pregnant patients and in females treated with hormonal contraceptives]. / Zur Kenntnis mikrokapillärer Angiome, Beobachtungen bei schwangeren bzw. unter hormoneller Antikonzeption stehenden Frauen.

We report on histological findings in 3 female patients, who developed microcapillary angiomas either during pregnancy or upon changing the oral contraceptive. These hemangiomas consisted of small, well-differentiated vessels located in the reticular dermis only and did not show any intra- or extravascular cell proliferation. We discuss the possible etiological factors of these microcapillary angiomas as well as the question of their correlation with pregnancy or hormonal contraceptives.

[Therapeutic results with tamoxifen in oligospermia. II. Hormonal analysis and semen parameters]. / Ergebnisse der Tamoxifen-Therapie bei Oligozoospermie. Teil II: Hormonanalysen und Ejakulatbefunde.

During a five months lasting treatment with tamoxifen (2 X 10 resp. 2 X 20 mg daily) a significant increase of testosterone, LH, FSH, estradiol, free testosterone and SHBG was found. The prolactin levels diminished. In semen analysis the values of pH and fructose decreased within the normal range. The sperm density increased significantly, but we could not ascertain whether a dosage of 2 X 20 mg/die will provide better therapeutic results. Furthermore the hormonal and seminal investigations described in this paper did not allow to predict those patients who would be good responders on tamoxifen therapy. Tamoxifen seems to be effective in normo-, but also in hypo- and hypergonadotropic patients.

[Tamoxifen treatment of oligospermia. Mechanism of action and metabolism]. / Ergebnisse der Tamoxifen-Therapie bei Oligozoospermie. I. Bemerkungen nhand klinischer Befunde und Laboratoriumsuntersuchungen.

210 males with idiopathic oligozoospermia or oligo-astheno-teratozoospermia were treated with tamoxifen (2 X 10 resp. 2 X 20 mg daily) over a period of five months. Investigations which were performed concomitantly revealed no significant changes in body weight, blood pressure, blood sedimentation rate, red and white blood count including the number of thrombocytes. In the multi-analysis of serum we found significant differences within the normal range concerning the following parameters: creatinine, albumin, cholesterol, phosphorus, sodium, calcium, alkaline phosphatase, LAP and gamma-GT. Most of those changes in serum values could be explained by an anabolic metabolism due to an increased testosterone level and by additional stress of the liver function. On 41 of those patients an ultrasonography of the testes was performed; in more than 50% the testicular volume increased during therapy with tamoxifen.