Efficacy comparison of rosuvastatin and atorvastatin in the treatment of atherosclerosis and drug safety analysis.

Previous studies have shown that the commonly used statin lipid lowering drugs can delay the progression of atherosclerotic plaque. Atorvastatin can stabilize atherosclerotic plaque, but it can not reverse atheromatous plaque. This study will compare the efficacy of rosuvastatin and atorvastatin in the treatment of atherosclerosis and try to prove that the use of statins can improve peripheral atherosclerosis and reverse atherosclerotic plaque. The results showed that 10 mg rosuvastatin was more effective than 20 mg atorvastatin in lowering serum lipid level and elevating ABI index, ABI as rosuvastatin group (0.782±0.236) and atorvastatin group(0.541±0.196). After 6 months of treatment, the carotid artery IMT in rosuvastatin group and atorvastatin group decreased compared with before treatment, and the difference was statistically significant (P<0.05). The TC/mmol⋅L-1 is 2.83±0.56 in rosuvastatin group and 3.24±0.71 in atorvastatin group. In addition, rosuvastatin did not increase the risk of adverse reactions compared with atorvastatin. The results confirm that statin therapy can improve peripheral atherosclerosis and reverse atherosclerotic plaques.

Effect of memantine on N-methyl-daspartate receptor in vascular dementia rats / 中华老年心脑血管病杂志

Objective To observe the effect of memantine on NR1 ,NR2A ,NR2B of N‐methyl‐das‐partate receptor and learning or memory ability in vascular dementia (VaD) rats .Methods Thirty adult male SD rats were randomly divided into sham operation group ,VaD model group and me‐mantine treatment group (10 in each group) .A rat VaD model was established by permanent liga‐tion of bilateral common carotid arteries .Rats in memantine treatment group received gastric me‐mantine 10 mg/(kg · d) 1 week after operation while those in model group received normal sa‐line .Five weeks after operation ,their learning or memory ability was tested by Morris water maze test ,expressions of NR1 ,NR2A and NR2B were detected by Western blot .Results The escape latency was significantly longer whereas the percentage of target quadrant and expression levels of NR1 ,NR2A and NR2B were significantly lower in model group than in sham operation group (P=0 .001 ,P=0 .002 ,P<0 .05) .The learning or memory ability and the expression levels of NR1 ,NR2A and NR2B were significantly higher in memantine treatment group than in model group but still lower in memantine treatment group than in sham operation group ( P< 0 .05) . Conclusion Memantine can improve the learning or memory ability of VaD rats by upregulating the expression of NR1 ,NR2A and NR2B in their hippocampus .

Argon plasma coagulation in the management of polyp remnants in colorectum / 中国组织工程研究

AIM: Remnant polyp tissues are often found after polypectomy. In this study, we assessed the outcome and safety of argon plasma coagulation (APC) in the management of colorectal sessile or semipedunculated polyp remnants after polypectomy. METHODS: Sixty-one colorectal polyps of 33 patients underwent polypectomy in Department of Digestion Medicine, Tangdu Hosptial, the Fourth Military Medical University of Chinese PLA from 2004 to 2007. Colorectal polyps type was identified by pathological examination. All polyps were removed under colonoscope with the diathermic snare, and the polyp remnants were destroyed with APC (Erbe, Germany). The power output was initially set at 40-50 W. In case of visibly insufficient coagulation, the output power was increased gradually by 5 W up until the remnants were completely ablated. Follow-up endoscopies were performed 1 and 3 months after the treatment. Pathological examination and APC treatment were performed when the recurrence of polyps was found. RESULTS: ①All 61 colorectal polyps were removed with the diathermic snare and the polyp remnants were destroyed with APC successfully only once. ②During the follow-up averaged 2.4 months, effective destruction of remnant polyp tissue was obtained in 59 polyps (96.7%) in 31 patients (93.9%). Colorectal polyp of two cases relapsed one month after treatment and identified as villous adenoma. ③Final power output was positively correlated with lesion size (r =0.97, P

Effect of sound produced by shooting a firearm on gastrointestinal transit of liquid food and its mechanism / 解放军医学杂志

0.05), but serum levels of, SS, SP and VIP were higher than those of control group (P05). When the intensity reached 120dB, gastrointestinal transit was accelerated significantly(P

Radiotherapy combined with the chemotherapy for 64 patients with advanced esophageal cancer / 中国癌症杂志

Purpose:To study the effect of radiotherapy combined with chemotherapy on advanced esophageal cancer. Methods:124 cases of advanced esophageal cancer were treated from March 1990 to April 1995. Patients were divided into 2 groups, including simple irradiation group receiving conventional radiotherapy to a total of 65～70 Gy; combined group which received the same radiotherapy as simple irradiation group plus chemotherapy with DFP or DF regimen. Both groups were followed for 5 years. Results:The short term results of radiotherapy combined with chemotherapy was better than that of radiotherapy alone. The difference between these two groups was statistically significant (P

Effect of explosive noise on gastrointestinal transit of solid food and its mechanism / 解放军医学杂志

0.05), and the serum levels of MLT, SS, SP, and VIP were higher than those of control group(P0.05). When the noise was higher than 80dB, gastrointestinal transit was increased significantly (P