RESUMO
BACKGROUND: Short time pretreatment with oxygen is reported to be protective against subsequent ischemia-reperfusion (IR) injury of heart and spinal cord in some animal models. The purpose of this study was to investigate the effects of pre-exposure to hyperoxic environment on rat renal IR injury for the first time. MATERIALS AND METHODS: The effects of 1 h/d pretreatment with oxygen (>or=95%) for 5 days on a right nephrectomized rat model of renal IR injury was investigated by comparing creatinine clearance, fractional excretion of sodium, plasma creatinine, blood urea nitrogen, and histological injury scores among three groups: IR (40 min ischemia-24 h reperfusion), sham (no IR), and hyperoxia (5 days intermittent pretreatment with oxygen + IR). RESULTS: Intermittent pretreatment with oxygen resulted in significant improvement of creatine clearance and fractional excretion of sodium (P Assuntos
Gases/uso terapêutico
, Nefropatias/prevenção & controle
, Rim/irrigação sanguínea
, Oxigenoterapia
, Oxigênio/uso terapêutico
, Traumatismo por Reperfusão/prevenção & controle
, Animais
, Nitrogênio da Ureia Sanguínea
, Creatinina/sangue
, Modelos Animais de Doenças
, Precondicionamento Isquêmico/métodos
, Masculino
, Ratos
, Ratos Wistar
, Sódio/urina