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INTRODUCTION: Matrix metalloproteinase-9 (MMP-9) plays an important role in the pathophysiology of sepsis. A single-nucleotide polymorphism (SNP) at position -1562 (C/T) in the MMP-9 gene has been associated with differential MMP-9 expression, being higher when the -1562 T allele is present. We evaluated the association of the SNP MMP9 -1562 C/T with severity and mortality in patients with sepsis to establish whether the prognosis of the disease is affected. MATERIALS AND METHODS: A case-control study exploratory was carried out in a cohort of infected patients. 540 individuals were selected in total, 270 patients with sepsis and 270 controls (infected but non-septic), classified according to the 2016 consensus (Sepsis-3). The presence of the single-nucleotide polymorphism (SNP; allele T and/or allele C) was determined through analyses of restriction fragment length polymorphism and plasma levels of MMP-9 were determined through enzyme-linked immunosorbent assay immunoassay. RESULTS: SNP MMP-9 -1562 has two known alleles (T and C), with predominance of the C over the T allele; in the group of patients with sepsis, T allele was found in 7.2% of cases, while C allele in the rest (92.8%); in comparison, in the group of infected but non-septic patients, frequencies were 9.4% for T allele and 90.6% for the C allele (P = .33). Also, the presence of the polymorphic T allele was not related to the levels of MMP-9 in patients with sepsis in comparison with infected but non-septic patients 780 (397-1375) ng/mL vs 646 (172-1249) ng/mL (P = .64). There was also no association between the SNP and sepsis mortality (P = .78). CONCLUSIONS: We concluded that there was no association between the SNP MMP9 -1562 C/T and sepsis or between the SNP MMP9 -1562 C/T and sepsis mortality in the Northeastern Colombian septic patient cohort. Further research is needed to clarify the correlation among sepsis, genetic factors with allele T and MMP-9 plasma concentration.
RESUMO
objetivos: Analizar los factores personales y familiares asociados a la depresión en los pacientes dela consulta externa dermatológica del Hospital Universidad del Norte y del Hospital Nazareth de laciudad de Barranquilla (Colombia).Resultados: Se encontró una fuerte asociación entre la presencia de depresión y los antecedentespersonales y familiares de la enfermedad, la evolución prolongada de la enfermedad dermatológica, laspérdidas laborales y afectivas, la presencia de enfermedad concomitante y la disfuncionalidad familiar.Conclusión: Los resultados sugieren que la depresión en los pacientes con trastornos dermatológicosestá asociada a la influencia de factores similares a los encontrados en la población general, a lo cualse añade el tiempo de evolución de la enfermedad dermatológica y la disfuncionalidad familiar.
Objectives: To analyze the association between personal and familiar factors and the presence ofdepression in dermatologic patients that attend the outpatient service at the Hospital Universidaddel Norte and the Hospital Nazareth in Barranquilla.Methods: A cross sectional study was designed within a population of 339 dermatology outpatients.The sample was selected by systematic sampling methods. Cases were defined as having some degreeof depression diagnosed by the Hamilton Rating Scale for Depression and controls as those who werenegative. Individual factors studied were: sex, marriage and economic status, length of evolution ofdermatological disorder, former history of depression, loss of job and loss of loved ones. Familiar factorsanalyzed were family history of psychiatric disorders, depression and familiar function. Data analysiswas computerized and the prevalence odds ratios (POR) and their confidence intervals werecalculated. The significance tests for association utilized were Chi-squared and Fisher.Results: Depression was associated to: personal and familiar background of depression, length ofevolution of the dermatological problem ...
