[The enzyme spectrum of the peripheral blood lymphocytes in patients with nonspecific lung diseases]. / Fermentnyi spektr limfotsitov perifericheskoi krovi u bol'nykh nespetsificheskimi zabolevaniiami legkikh.

The data on the activity of the enzymes of xenobiotic metabolism in peripheral blood lymphocytes point to essential disorders within the system of detoxification in patients with bronchopulmonary pathology. The necessity of cultivating cells with mitogens before measurement of the activity of the enzymes of xenobiotic metabolism of the first phase (cytochrome P-450, cytochrome C-reductase) for more precise measurement and reproducibility of the results is discussed. Study of the activity of cytosol enzymes of the second phase (glutathione-S-transferase, sulfotransferase) does not require preliminary cell cultivation. The authors emphasize the importance of studying the enzymes of xenobiotic metabolism to individualize the treatment and choose optimal drug doses.