Exploration of home care nurse's experiences in deprescribing of medications: a qualitative descriptive study.

OBJECTIVES: The aim of this study is to explore the barriers and enablers of deprescribing from the perspectives of home care nurses, as well as to conduct a scalability assessment of an educational plan to address the learning needs of home care nurses about deprescribing. METHODS: This study employed an exploratory qualitative descriptive research design, using scalability assessment from two focus groups with a total of 11 home care nurses in Ontario, Canada. Thematic analysis was used to derive themes about home care nurse's perspectives about barriers and enablers of deprescribing, as well as learning needs in relation to deprescribing approaches. RESULTS: Home care nurse's identified challenges for managing polypharmacy in older adults in home care settings, including a lack of open communication and inconsistent medication reconciliation practices. Additionally, inadequate partnership and ineffective collaboration between interprofessional healthcare providers were identified as major barriers to safe deprescribing. Furthermore, home care nurses highlighted the importance of raising awareness about deprescribing in the community, and they emphasised the need for a consistent and standardised approach in educating healthcare providers, informal caregivers and older adults about the best practices of safe deprescribing. CONCLUSION: Targeted deprescribing approaches are important in home care for optimising medication management and reducing polypharmacy in older adults. Nurses in home care play a vital role in medication management and, therefore, educational programmes must be developed to support their awareness and understanding of deprescribing. Study findings highlighted the need for the future improvement of existing programmes about safer medication management through the development of a supportive and collaborative relationship among the home care team, frail older adults and their informal caregivers.

Investigating the effectiveness of school-based breastfeeding education on breastfeeding knowledge, attitudes and intentions of adolescent females.

Breastfeeding intentions are usually shaped prior to conception, often as early as adolescence. Secondary school reproductive curriculum may be an appropriate setting to provide breastfeeding information on a population level. The purpose of this pilot study was to investigate the impact of a school-based breastfeeding educational intervention on the breastfeeding knowledge, attitudes and future infant feeding intentions of secondary school adolescent females; as well as assess the acceptability and feasibility of the intervention among the target population. Participants consisted of a convenience sample of 77 adolescent female students from an Ontario secondary school. Participants received one 70 min breastfeeding educational session in health education class. Data were collected using self-administered questionnaire at baseline and one day after the intervention. A modified version of the Iowa Infant Feeding Attitude Scale (IIFAS) and a modified breastfeeding knowledge scale were used to measure breastfeeding attitudes and knowledge. Additional outcomes measured included future breastfeeding intentions and participants' perceptions of the educational session. Breastfeeding knowledge (p < 0.001), attitudes (p < 0.001), and future intentions of participants to exclusively breastfeed increased significantly (p < 0.05) at post-test. The participant feedback indicated that they found the content useful, interesting and the information was presented in an engaging manner. These findings suggest that adolescent females are receptive to learning about breastfeeding in school and a single school-based breastfeeding educational intervention can positively impact breastfeeding knowledge, attitudes and future intentions of adolescent females. The secondary school setting may be an ideal setting for the inclusion of educational breastfeeding content to enable future informed decision making.

Evaluating the test-retest reliability of the SLUMP questionnaire for measuring biomechanical issues during laptop use among university students.

BACKGROUND: Laptop use may be associated with poor health among University students. However, no psychometrically-sound instrument is available to measure biomechanical issues during laptop computer use in this population. OBJECTIVE: To evaluate the test-retest reliability of the Student Laptop Use and Musculoskeletal Posture (SLUMP) questionnaire among undergraduate University students. PARTICIPANTS: We invited 179 undergraduate students from two Health Sciences courses at the University of Ontario Institute of Technology to participate in the study in October 2015. METHODS: We conducted a test-retest reliability study. The SLUMP questionnaire, which includes 51 questions, was administered twice at a seven-day interval. We used weighted Kappa statistics to calculate test-retest reliability. RESULTS: Ninety-one students completed the study. 72.5% of the 51 questions achieved a Kw≥0.60 with 29.4% of questions achieving a Kw≥0.80. The reliability was similar for males and females. CONCLUSION: The SLUMP offers a promising method to measure biomechanical issues during laptop use among University students.

Developing and evaluating the feasibility of administering the SLUMP questionnaire for evaluating ergonomic exposures to laptop use in university students.

BACKGROUND: Laptop computer use may lead to the development of health problems. However, few methods exist to measure laptop use in undergraduate students. OBJECTIVES: To develop a web-based questionnaire to measure ergonomic exposures to laptop use and to test the feasibility of administration in university students. METHODS: We pilot tested the administration of the Student Laptop Use and Musculoskeletal Posture (SLUMP) questionnaire to 44 second year undergraduate students. We measured the participation rate, completion of questions, and sought feedback for improving the questionnaire. RESULTS: The participation rate was 75% (33/44). Students needed 10-12 minutes to complete the questionnaire. Participants suggested adding half hour intervals for questions measuring breaks and improving the clarity by emphasizing the sections focusing on academic, recreational and employment laptop use. CONCLUSION: Our pilot study suggests that the SLUMP questionnaire is appropriate for "in-class" measurement of ergonomic exposures to laptop use in university students.

Sociodemographic predictors of tobacco smoking among expatriate and national adolescents in the United Arab Emirates.

BACKGROUND: Tobacco use among adolescents is an important public health concern as it causes various forms of smokingrelated health problems and can create a gateway for other substance abuse. AIM: This study examined the prevalence, profile and predictors of tobacco use among expatriate and national adolescents living in the United Arab Emirates (UAE). METHODS: Using a cross-sectional study design (2007-2009), we collected data on the prevalence of tobacco use in 6363 adolescents aged 13-20 years, including current smokers of cigarettes, midwakh, shisha and any other form of tobacco. We also collected demographic, socioeconomic, residential and behavioural data. RESULTS: In the previous 30 days, 505 (8.9%) participants had smoked cigarettes, 355 (6.3%) had smoked midwakh, 421 (7.4%) had smoked shisha and 380 (6.4%) had smoked any other form of tobacco. Overall, 818 (14.0%) adolescents were current smokers, who reported occasional or daily use of at least one form of tobacco in the past 30 days. Results consistently indicated that the prevalence of tobacco use was higher among men than women, regardless of age and tobacco form. Among men, cigarette smoking was the most popular, whereas shisha was the most smoked form of tobacco among women. Being male and ever having used illegal drugs consistently emerged as significant predictors of all forms of tobacco use. CONCLUSION: There is a need for continued public health strategies and education campaigns to discourage adolescents in the UAE from using tobacco.

Prevalence and predictors of over-the-counter medication use among adolescents in the United Arab Emirates.

The patterns of over-the-counter medication (OTC) usage among adolescents living in the United Arab Emirates (UAE) remains largely understudied. The objectives of this study are: (1) to determine the profile of OTC use among UAE adolescents; and (2) to determine the biological or physical, psychological or behavioural, and social predictors of OTC use among the UAE adolescent population. Using a cross-sectional study design, data were collected on the prevalence of OTC use for a sample of 6363 adolescents. Overall, 51% of participants in this study reported OTC use. The most common form of OTC used was acetaminophen. Significant predictors of OTC use were: nationality (UAE, GCC, Arab / Middle East, Arab / Africa, Western, other); needed health care but did not receive it; sex (female); age (15-18 years); any medical diagnosis; unconventional drug use; spending more than 5 hours using TV and computer daily; and using prescription medicines. Thus, there is a need to develop public health policies and strategies that promote appropriate use of OTC in the population.

A longitudinal cohort study examining determinants of overweight and obesity in adulthood.

OBJECTIVES: Adulthood overweight and obesity are multifaceted conditions influenced by a combination of biological, environmental and socio-cultural factors across the lifespan. Using a longitudinal study design, we aimed to identify determinants of adulthood overweight and obesity, in relation to: 1) childhood and life course factors, 2) geographical differences in air quality, and 3) gender-specific factors, in a cohort followed from childhood into adulthood. METHODS: Childhood data were acquired (1978-1986) from children residing in four distinct Hamilton neighbourhoods (Ontario, Canada), including air-quality assessments. Adulthood data were obtained (2006-2007) from successfully retraced participants (n = 315) using comprehensive self-administered questionnaires. Multivariate logistic regressions were used to evaluate determinants of adulthood overweight (BMI: 25-29.9 kg/m2) and obesity (BMI: ≥30). RESULTS: The prevalence of normal weight decreased drastically at follow-up in adulthood, while that of overweight and obesity increased. Both overweight and obesity in adulthood were associated with male gender and occupational exposures to contaminants. Childhood residence in Hamilton neighbourhoods with better air quality was associated with lesser odds of adulthood overweight, whereas adulthood obesity was strongly linked to childhood weight gain (overweight or obesity). Among females, childhood weight status predicted overweight and obesity in adulthood, with always living in Hamilton, lack of additional health insurance, negative self-appraisal and high blood pressure during adulthood identified as other significant predictors. Among males, prolonged occupational exposures to contaminants emerged as a unique determinant of adulthood weight gain. CONCLUSION: Adulthood overweight and obesity are associated with childhood and life course determinants, including childhood weight status, residential air quality and occupational contaminant exposures, in a gender-specific manner.

Determinants of neurological disease: Synthesis of systematic reviews.

Systematic reviews were conducted to identify risk factors associated with the onset and progression of 14 neurological conditions, prioritized as a component of the National Population Health Study of Neurological Conditions. These systematic reviews provided a basis for evaluating the weight of evidence of evidence for risk factors for the onset and progression of the 14 individual neurological conditions considered. A number of risk factors associated with an increased risk of onset for more than one condition, including exposure to pesticides (associated with an increased risk of AD, amyotrophic lateral sclerosis, brain tumours, and PD; smoking (AD, MS); and infection (MS, Tourette syndrome). Coffee and tea intake was associated with a decreased risk of onset of both dystonia and PD. Further understanding of the etiology of priority neurological conditions will be helpful in focusing future research initiatives and in the development of interventions to reduce the burden associated with neurological conditions in Canada and internationally.

A systematic review of risk factors associated with muscular dystrophies.

The purpose of this study was to systematically review, assess, and prioritize factors (including biological, socioeconomic, environmental, psychosocial, comorbid, and genetic) for the onset and natural progression of Muscular Dystrophy. Comprehensive review of current literature of these factors was carried out in order to provide a basis for policy makers to identify appropriate measures to mitigate the burden of disease in Canada. A three-stage approach to searching for relevant studies was conducted in multiple databases. Using variations of MeSH terms and keywords, Systematic reviews or meta-analyses published in English or French that meet the inclusion criteria were first identified, then searched for relevant observational studies. Two independent reviewers screened abstracts, then qualifying articles, conducted quality assessment, and finally extracted relevant data using the application, DistillerSR. No existing systematic reviews, meta-analyses, or non-genetic observational studies were identified that met the inclusion criteria. A number of existing systematic reviews and observational studies focused on pharmacological or therapeutic interventions, which was beyond the scope of this study. Four genetic observational studies were identified that focused on aspects of disease progression of Duchenne and Becker Muscular Dystrophy. While this systematic review found that certain genetic polymorphisms and mutations may be a factor for Duchenne or Becker Muscular Dystrophy disease progression, further investigation into other genetic factors and environmental factors is still warranted. Much of the current literature focuses on these Muscular Dystrophies, however, other types of Muscular Dystrophy and their associated risk factors have yet to be extensively studied.

Onset factors in cerebral palsy: A systematic review.

Studies have noted several factors associated with the occurrence of Cerebral Palsy (CP), yet considerable uncertainty remains about modifiable factors related to disease onset. A systematic review was performed to identify existing systematic reviews and primary studies pertaining to targeted factors associated with the onset of CP. The following databases were searched: MEDLINE, MEDLINE In Process, EMBASE, PsycINFO, Scopus, Web of Science, Cochrane Database of Systematic Reviews, CINHAL, ProQuest Dissertations & Theses, Huge Navigator, AARP Ageline. Variations of MeSH and keyword search terms were used. Critical appraisal was conducted on selected articles. Data extraction targeted reported factors, risk estimates, and 95% confidence intervals (CI). Findings identified two systematic reviews and three meta- analyses, as well as 83 studies of case control, cohort, and cross-sectional methodological designs. Selected studies indicated that lower gestational age was associated with the onset of CP. Medical diagnoses for the mother, in particular chorioamnionitis, was found to be positively associated with onset of CP. Preeclampsia was reported to be either inconclusive or positively associated with CP onset. Low birth weight predominantly indicated a positive association with the onset of CP, while male gender showed mixed findings. The combination of male gender with pre-term or low birth weight was also found to be positively associated with CP. Evidence was identified in the literature pertaining to specific factors relating to the onset of CP, in particular showing positive associations with lower gestational age and low birth weight.

Onset and progression factors in Parkinson's disease: A systematic review.

Current research has identified several factors thought to be associated with the onset and progression of Parkinson's Disease (PD); however, whether certain factors contribute to or are protective against PD remains unclear. As such, a systematic search of the literature was performed using variations of MeSH and keyword search terms to identify and summarize systematic reviews and primary studies pertaining to factors associated with the onset and progression of PD. Factors referred to both traditional risk factors and prodromal markers. The following databases were searched: MEDLINE, MEDLINE In-Process, EMBASE, PsycINFO, Scopus, Web of Science, Cochrane Database of Systematic Reviews, Cumulative Index to Nursing and Allied Health Literature (CINAHL), ProQuest Dissertations & Theses, AARP AgeLine, and PDGene. A quality assessment of included systematic reviews was completed using the validated Assessment of the Methodological Quality of Systematic Reviews (AMSTAR) tool. Data extraction targeted reported factors, risk estimates, and 95% confidence intervals (CI). Findings identified 11 systematic reviews of sufficient quality reporting factors for PD onset, and no systematic reviews reporting factors for PD progression. In addition, 93 primary articles were identified, of which, 89 articles addressed factors related to PD onset and 4 articles addressed factors related to the PD progression. Pesticide exposure, rural living, well-water drinking, and farming occupation were consistently found to be positively associated with the onset of PD. Moreover, family history and polymorphisms to key genes were also found to be positively associated with the onset of PD. Conversely, coffee consumption, cigarette smoking, and some polymorphisms were consistently found to be negatively associated with the onset of PD. Urate was the only identified factor linked to the progression of PD; it was mostly found to be negatively associated with PD. In sum, the evidence was systematically found and summarized in the literature pertaining to factors related to the onset and progression of PD.

Genetic variation associated with the occurrence and progression of neurological disorders.

This paper presents an overview of genetic variation associated with the onset and progression of 14 neurological disorders, focusing primarily on association studies. The 14 disorders are heterogeneous in terms of their frequency, age of onset, etiology and progression. There is substantially less evidence on progression than onset. With regard to onset, the conditions are diverse in terms of their epidemiology and patterns of familial aggregation. While the muscular dystrophies and Huntington's disease are monogenic diseases, for the other 12 conditions only a small proportion of cases is associated with specific genetic syndromes or mutations. Excluding these, some familial aggregation remains for the majority of cases. There is considerable variation in the volume of evidence by condition, and by gene within condition. The volume of evidence is greatest for Alzheimer's disease, Parkinson's disease, multiple sclerosis and amyotrophic lateral sclerosis. As for common complex chronic diseases, genome wide association studies have found that validated genomic regions account for a low proportion of heritability. Apart from multiple sclerosis, which shares several susceptibility loci with other immune-related disorders, variation at HLA-DRB5 being associated both with Parkinson's disease and Alzheimer's disease, and the association of the C9orf72 repeat expansion with ALS and frontotemporal degeneration, there was little evidence of gene loci being consistently associated with more than one neurological condition or with other conditions. With the exception of spina bifida, for which maternal MTHFR genotype is associated with risk in the offspring, and corroborates other evidence of the importance of folate in etiology, there was little evidence that the pathways influenced by genetic variation are related to known lifestyle or environmental exposures.

Air Quality and Respiratory Health among Adolescents from the United Arab Emirates.

PURPOSE: To examine the role of air quality in relation to chronic bronchitis, emphysema, asthma, wheeze, and dry cough among adolescents from the United Arab Emirates (UAE). METHODS: A survey was administered on 6,363 adolescents from 9 UAE regions. Data consists of demographic, socioeconomic, residential, and behavioural variables, such as location of residence, residing near industry/gas stations/dumpsites/construction sites, residing near overhead power line/plants, exposure to tobacco, residential exposure, ethnicity, concern over air pollution, smoking, and purposely smelling gasoline fumes/glue/correctors/car exhaust/burning black ants. Logistic regression modeling was used to determine significant predictors of respiratory health. RESULTS: Asthma prevalence was 12.3%, followed by chronic bronchitis (1.8%) and emphysema (0.5%). Overall 12.2% reported wheeze and 34.8% reported a dry nocturnal cough in the past year. Multivariate analyses suggest that sex is a significant predictor of asthma and dry cough. Exposure to tobacco and arts/crafts/ceramics/stain is significant predictor of respiratory health. Tobacco smoking and purposely smelling gasoline fumes/glue/correctors/car exhaust/burning black ants are significant predictors of wheeze and dry cough. CONCLUSIONS: This study suggests that exposure to air quality and behavioral factors such as smoking and purposely smelling gasoline fumes, glue, correctors, car exhaust, or burning black ants are significant predictors of respiratory health among UAE adolescents.

Injuries among adolescents in the United Arab Emirates.

This study examines the profile of injuries among adolescents in the United Arab Emirates (UAE) and identifies related factors associated with injury. A cross-sectional study design determined incidence of injury for a sample of 6363 adolescents. Data collected information on injury in the past 12 months, socio-demographic, behavioural and sensory data. Logistic regression modelling was used to examine predictors of physical injury for the past 12 months. Among participants, 18% experienced injury; the three top causes include accidental falls (38%), being struck by an object or person (18%), and motor vehicle injuries (MVI) (13%). The majority of injuries took place at the participant's home and surrounding area. Identified risk factors that are amenable for prevention include smoking behaviour, exposure to smoking, physical activity profile, family income, and speeding behaviour. Our findings highlight the need for public health policies and education programmes that reduce injury among the UAE adolescent population.

Prevalence of high blood pressure, heart disease, thalassemia, sickle-cell anemia, and iron-deficiency anemia among the UAE adolescent population.

This study examined the prevalence of high blood pressure, heart disease, and medical diagnoses in relation to blood disorders, among 6,329 adolescent students (age 15 to 18 years) who reside in the United Arab Emirates (UAE). Findings indicated that the overall prevalence of high blood pressure and heart disease was 1.8% and 1.3%, respectively. Overall, the prevalence for thalassemia, sickle-cell anemia, and iron-deficiency anemia was 0.9%, 1.6%, and 5%, respectively. Bivariate analysis revealed statistically significant differences in the prevalence of high blood pressure among the local and expatriate adolescent population in the Emirate of Sharjah. Similarly, statistically significant differences in the prevalence of iron-deficiency anemia were observed among the local and expatriate population in Abu Dhabi city, the western region of Abu Dhabi, and Al-Ain. Multivariate analysis revealed the following significant predictors of high blood pressure: residing in proximity to industry, nonconventional substance abuse, and age when smoking or exposure to smoking began. Ethnicity was a significant predictor of heart disease, thalassemia, sickle-cell anemia, and iron-deficiency anemia. In addition, predictors of thalassemia included gender (female) and participating in physical activity. Participants diagnosed with sickle-cell anemia and iron-deficiency anemia were more likely to experience different physical activities.

Health impacts of air pollution: a life course approach for examining predictors of respiratory health in adulthood.

PURPOSE: This research applies a life course health development framework to examine the impacts of childhood exposure to air pollution on respiratory health in adulthood. METHODS: This prospective cohort study uses data collected from children originally studied in the 1970/1980s, including exposure to air pollution, indoor exposures, sociodemographic variables, and health outcomes data. Thirty years later, a self-administered questionnaire was used to collect data from adulthood on health status, occupational and residential histories, socioeconomic status, and lifestyle. RESULTS: Overall, 29% of respondents were diagnosed with at least one respiratory condition and 24% have persistent respiratory symptoms in adulthood. Significant neighborhood differences in exposure variables and adulthood health outcomes were found. Predictors of adulthood respiratory health include asthma diagnosis or chest illness in childhood, parental record of respiratory symptoms, other medical diagnosis in adulthood, fair/poor self-perceived health, smoking/exposure to smoking, and residing in a property built before 1950. Results suggest that exposure to ambient total suspended particulates in childhood is preventative for diagnosis with at least one respiratory condition in adulthood. CONCLUSION: Findings suggest that long-term childhood exposure to air pollution does not predict respiratory conditions and symptoms in adulthood. However, respiratory health in childhood predicts adulthood respiratory health, thus suggesting that the health impacts of any exposures that impact respiratory health during critical or sensitive times in childhood are long term.

Predictors of locating children participants in epidemiological studies 20 years after last contact: Internet resources and longitudinal research.

This study examines predictors of locating participants that were last contacted 20 years ago using public web-search directories, in order to facilitate longitudinal environmental health research. Participants (n = 3,202) resided in four distinct geographical neighborhoods in Hamilton, Ontario during childhood; they were between 15 and 17 years old when they were last contacted in 1986. Data used for tracing included available addresses, telephone numbers, given names, and parental names. Reverse and forward search strategies were used to retrieve updated contact details. 43% of the sample was traced using online directories. Following ethical approval, participants were contacted using traced data and 29% of the original cohort was located. Predictors of locating participants were: availability of paternal names, being traced to original addresses or telephone numbers, gender (male), relatively higher socioeconomic status in childhood, and not being exposed to smoking in childhood. Where participants resided in childhood was not a significant predictor of locating participants. Although 13% of the sample was traced using forward search by name, only 4% were located. For participants traced to available addresses or telephone numbers, the difference between the proportions of traced and located participants was <3%. Prospective studies on children may benefit from including the listed names that pertain to each child's telephone number and full parental names at recruitment, thereby increasing the likelihood of locating participants using Internet resources. Integrating the use of Internet-based public directories for cohort reconstruction can reduce financial costs related to follow-up for longitudinal research.