[Hyperkinetic symptoms in children and adolescents with psychosomatic disorders].

Authors studied 151 patients with psychosomatic diseases with attention deficit of different severity and hyperkinetic disorders. Based on the results obtained in the study, it was suggested an affective- disontogenetic conception of hyperkinetic disorders in children and adolescents. A significant role of both biological and psychosocial factors as well as gender and age differences in the development and formation of activity and attention disorders is emphasized. The frequency of these factors was correlated with clinical specifics of hyperkinetic disorders. The correlation between specifics of hyperkinetic disorders and affective disorders (subdepression) was confirmed by the high effectiveness of differential psychopharmacotherapy with antidepressants.

[Trisomy of the distal 15q region due to familial balanced translocation t(15;16)(q24;p13) and unusual mosaicism in the mother of the proband]. / Trisomiia po distal'nomu uchastku 15q, obuslovlennaia semeinoi sbalansirovannoi translokatsiei t(15;16)(q24;p13), i neobychnyi mozaitsizm u materi probanda.

Clinic-cytogenetic analysis of the patient with distal 15q trisomy is presented. Proband's mother and grandmother are carriers of the balanced translocation t (15; 16) (q24; p13). Phenotypically normal proband's mother has a second cell clone with repaired marker chromosome 15 which participates in the balanced translocation of the main cell line. It is supposed possible to repair translocated human chromosomes as a result of mitotic recombination process.

[Intra-individual polymorphism of human Y chromosome as a result of deletion in the heterochromatin region]. / Vnutriindividual'nyi polimorfizm Y-khromosomy cheloveka kak sledstvie deletsii geterokhromatinovogo bloka.

Two equal cell populations with Y-heterochromatin of different lengths were found in a sterile male with azoospermia. There was no evidence for translocation of the heterochromatic material to other chromosomes. Both cell lines have the same Q-, C- and Ag-NOR patterns of chromosomal differential staining. The Y-chromosomes of both the father and brother were as long as the longest of the two populations in the proband. This intraindividual heteromorphism of Y-chromosome is, probably, a result of Y-heterochromatin deletion during the first mitotic division of the zygote, with the loss of a fragment as long as the difference between the long and the short Y populations in the proband. Intraindividual chromosomal heteromorphism is a convenient model to study reasons for variability in the heterochromatin regions of chromosomes.