[Induction of differentiation of leukemic cells]. / Induktsiia differentsirovki leikoznykh kletok.

The review is devoted to news facts in support of the conception advanced by R.E. Kavetsky and others scientists on the possibility of normalization of malignant cell properties due to differentiation increase of these cells under the effect of different inducers. The role and possible mechanisms of viral and cellular oncogenes in cell differentiation are considered. Model cell systems have been chosen as an example to illustrate the involvement of particular oncogenes in haematopoietic cell differentiation. Different mechanisms of oncogenes involvement in cell growth control and differentiation are under discussion.

[Differentiation of human leukemia K-562 cells in diffusion chambers]. / Differentsirovka leikoznykh kletok cheloveka linii K-562 v diffuzionnykh kamerakh.

The human leukemia K562 cells differentiation is studied in diffusion chambers implanted in rats intraperitoneally. The investigations revealed the possibility of explantation of leukemic K562 cells in diffusion chambers in a heterogeneous host. The ability of these cells to follow the myeloid lineage of differentiation is shown.