Quantitative Flow Ratio for Assessment of Non-Culprit Coronary Artery Lesions During Percutaneous Coronary Intervention (PCI) in 79 Patients Diagnosed with ST-Elevation Myocardial Infarction (STEMI): A Study from a Single Center in Lithuania.

BACKGROUND Approximately half of the patients requiring percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction (STEMI) have additional stenotic coronary artery (CA) lesions in non-infarct-related arteries (non-IRA). This study from a single center in Lithuania aimed to evaluate the use of the quantitative flow ratio (QFR) in assessing non-IRA lesions during PCI in 79 patients diagnosed with STEMI. MATERIAL AND METHODS We prospectively included 105 vessels of 79 patients with worldwide STEMI criteria and ≥1 intermediate (35-75%) lesion in non-IRA between July 2020 and June 2021. For all included patients, QFR analyses were performed twice, during the index PCI (QFR 1) and during a staged procedure ≥3 months later (QFR 2). The QFR analyses were performed with the QAngio-XA 3D and £0.80 were used as cut-off values for PCI. The primary endpoint was a head-to-head numerical agreement between 2 measurements. RESULTS An excellent numerical agreement was found in all investigated lesions, r=0.931, p<0.001, left anterior descending (LAD) r=0.911, p<0.001, left circumflex (LCx) r=0.977, p<0.001, and right coronary artery (RCA) 0.946, p<0.001. Clinical treatment decision-making showed amazing agreement between the 1st and the 2nd QFR analyses, r=0.980, p<0.001. There was 1 disagreement between QFR 1 and QFR 2. CONCLUSIONS The findings from this support previous studies and showed that the QFR is a practical quantitative method to evaluate non-IRA lesions, which in this study included STEMI patients during PCI following occlusive CA stenosis.

Quantitative flow ratio vs. angiography-only guided PCI in STEMI patients: one-year cardiovascular outcomes.

BACKGROUND: Coronary physiology-guided PCIs are recommended worldwide. However, invasive coronary physiology methods prolong the procedure, create additional risks for the patients, and prolong the fluoroscopy time for an interventional cardiologist. Otherwise, there is a noninvasive coronary physiology evaluation method, QFR, that can be safely used even in STEMI patients. METHODS: A total of 198 patients admitted with STEMI and at least one intermediate (35-75%) diameter stenosis other than the culprit artery between July 2020 and June 2021 were prospectively included in this single-center study. All patients were randomized into one of two groups (1 - QFR-guided PCI; 2 - visual-estimation-only guided PCI). A 12-month follow-up with echocardiography, exercise stress test, and quality of life evaluation was performed in all included patients. For the QOF evaluation, the Seattle Angina Score Questionnaire was chosen. Statistical analysis was performed using the Kolmogorov-Smirnov test, Student's t-test, Mann-Whitney U test, Pearson's chi-squared test and Kaplan-Meier estimator. RESULTS: Ninety-eight (49.5%) patients were randomized to the first group, and 100 (50.5%) patients were included in the second group. Statistically, significantly more patients had a medical history of dyslipidemia (98 vs. 91, p = 0.002) and slightly better left ventricular ejection fraction (42.21 ± 7.88 vs. 39.45 ± 9.62, p = 0.045) in the QFR group. Six fewer patients required non-culprit artery revascularization within the 12-month FU in the QFR group (1.02% vs. 6%, p = 0.047). Survival analysis proved that patients in the Angio group had a more than 6-fold greater risk for death within a 12-month period after MI (OR 6.23, 95% CI 2.20-17.87, p = 0.006), with the highest mortality risk within the first two months after initial treatment. CONCLUSION: Using QFR in non-culprit lesions in patients with ST-elevation myocardial infarction reduces mortality and revascularization at the 12-month follow-up and improves the quality of life of the patient. TRIAL REGISTRATION: The study was approved by the Regional Bioethical Committee and conducted under the principles of the Helsinki Declaration and local laws and regulations.

Outcomes of in-hospital treatment of cardiac patients who survived cardiac arrest and experienced coronary angiography.

INTRODUCTION: As coronary artery disease is the most frequent cause of cardiac arrest, early invasive strategies may be beneficial for such patients. This study analyses the impact of in-hospital treatment on short-term outcomes of out-of-hospital cardiac arrest (OHCA) survivors. MATERIAL AND METHODS: Patients admitted to the Cardiac Intensive Care Unit of our hospital within 2-year period were prospectively included in the study. RESULTS: One hundred thirty-one patients were included in the study, which showed that in-hospital mortality increases uniformly with the severity of the coronary artery lesion (p = 0.044), but an effect of revascularization on number of deaths was not observed (p = 0.64). The presence of coma (p = 0.005) and the combination of male sex and age above 60-year as 2.2-fold (p = 0.048) increasing in-hospital mortality were found. The highest mortality rate occurred during the first 3 days and the death rate of the patients who survived this period is low. We found reduced left ventricular ejection fraction (OR = 6.54; 95% CI: 1.98-21.63; p = 0.002), non-ventricular fibrillation initial rhythm (OR = 2.94; 95% CI: 1.25-6.90; p = 0.014), unconscious at admission (OR = 6.46; 95% CI: 1.96-21.24; p = 0.002) and post-resuscitation coma (OR = 6.00; 95% CI: 2.63-13.66; p < 0.001) or encephalopathy (OR = 2.71; 95% CI: 1.9-6.72; p = 0.031) to be significant prognostic factors for higher in-hospital mortality rate. CONCLUSIONS: We recommend immediate coronary interventions for all survivors of OHCA regardless of their state of consciousness and absence of ischaemic changes on ECG. Early intensive treatment for OHCA patients is indispensable, as the highest mortality rate is within the first 3 days after an event.

The impact of clinical and angiographic factors on percutaneous coronary angioplasty outcomes in patients with acute ST-elevation myocardial infarction.

INTRODUCTION: Percutaneous coronary intervention (PCI) outcomes are dependent on certain clinical and angiographic factors. The impact of modifiable cardiovascular disease (CVD) risk factors on PCI outcomes is still controversial. The aim of the study was to evaluate the impact of clinical and angiographic factors on PCI outcomes for patients with acute ST-elevation myocardial infarction (STEMI). MATERIAL AND METHODS: Age, gender, CVD risk factors, Killip class and culprit coronary artery (CA) localization, total CA occlusion, initial and post-procedural thrombolysis in myocardial infarction (TIMI) flow grade, and thrombus aspiration characteristics were assessed retrospectively in 188 consecutive patients with STEMI who underwent primary PCI. Spearman's rho test was performed to assess hospital stay correlations, and logistic regression was applied to identify predictors of distal embolization (DE), in-hospital worsening of heart failure (WHF), and in-hospital mortality rate. Local ethics committee approval was obtained for the study. RESULTS: DE occurred in 12 (6.4%) patients. In-hospital WHF was diagnosed in 16 (8.5%) patients. Twelve (6.4%) patients died in hospital. Age had a positive weak correlation with hospital stay and was an independent predictor of distal embolization, in-hospital worsening of heart failure, and in-hospital mortality rate. Killip class, left main CA stenosis (> 50.0%), and post-procedural TIMI flow grade 1-2 were other predictors of death in hospital. CONCLUSIONS: Age was an independent predictor of distal embolization, in-hospital worsening of heart failure, and in-hospital mortality. Other independent predictors of in-hospital mortality rate were Killip class, left main CA stenosis (> 50.0%), and post-procedural TIMI flow grade 1-2. The present analysis highlighted the "cholesterol paradox" with respect to in-hospital worsening of heart failure and mortality in hospital.