RESUMO
Regarding the importance of benziodarone (Retrangor) -- 2-ethyl-3-(3',5'-diiodo-4'-hidrovibenzoyl)benzofuran -- in medical practic, in respect of its vasodilator and uricosuric action, a working plan was developed intending to study the biological distribution of the drug in rats Wistar and, using the plasmatic curve, to find out the existence of other compartements besides the intravascular one. With these data, the rhytms of benziodarone exchange were established, simulating its distribution in the organism. It was possible to develop this working project because the benziodarone structure could be labelled with iodine-131, using an isotopic exchange reaction, having chloramine T as an oxidant agent. The labelled compound was employed as radioactive tracer, and its specific activities varied from 18 uCi/mg to 20 uCi/mg.
