RESUMO
PURPOSE: To report a case of posterior uveitis with retinal neovascularization in a patient with Behçet disease treated with infliximab. METHODS: A 50-year-old man with a history of recurrent relapses of ocular inflammation despite immunosuppressive therapy developed retinal neovascularization near the optic disk. The patient was treated with infliximab and followed up for 12 months. RESULTS: Retinal neovascularization regressed 8 months after the first anti-tumor necrosis factor (TNF) treatment and with six infusions of infliximab. The ocular inflammation resolved almost completely. CONCLUSIONS: The result suggests that anti-TNF therapy may be effective in the treatment of retinal neovascularization caused by panuveitis in Behçet disease.
Assuntos
Anticorpos Monoclonais/uso terapêutico , Antirreumáticos/uso terapêutico , Síndrome de Behçet/tratamento farmacológico , Neovascularização Retiniana/tratamento farmacológico , Uveíte Posterior/tratamento farmacológico , Adulto , Síndrome de Behçet/complicações , Angiofluoresceinografia , Fundo de Olho , Humanos , Infliximab , Masculino , Neovascularização Retiniana/etiologia , Resultado do Tratamento , Uveíte Posterior/etiologia , Acuidade VisualRESUMO
PURPOSE: To report a case of posterior uveitis with retinal neovascularization in a patient with Behet disease treated with infliximab. METHODS: A 50-year-old man with a history of recurrent relapses of ocular inflammation despite immunosuppressive therapy developed retinal neovascularization near the optic disk. The patient was treated with infliximab and followed up for 12 months. RESULTS: Retinal neovascularization regressed 8 months after the first antitumor necrosis factor (TNF) treatment and with six infusions of infliximab. The ocular inflammation resolved almost completely. CONCLUSIONS: The result suggests that anti-TNF therapy may be effective in the treatment of retinal neovascularization caused by panuveitis in Behet disease. (Eur J Ophthalmol 2004; 14: #-8).
RESUMO
Nowadays the role of sonography (US) as a method of first choice in female pelvic pathology, is well determined. The authors used sonography in 23 patients aged between 13 and 36 years, affected by thalassemia major, in order to determine biometric and structural data of both uterus and ovaries. Morphological and clinical-laboratory studies have been performed in order to have a complete vision about the delay in ovarian maturation, commonly seen in these patients. Many cases of hypoplastic uterus and micropolycystic ovaries have been found. US, simple and widely diffused method, allow the evaluation of uterine and ovarian pathologic conditions and the relationship with ovarian maturation delay, and their follow-up. In some cases US may have a value in previewing menarche, in association with clinical-laboratory data.
