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Ann Pharm Fr ; 48(1): 1-6, 1990.
Artigo em Francês | MEDLINE | ID: mdl-2082795

RESUMO

Several new derivatives of the aldehydic functions of (+/-) gossypol are described: an hydrosoluble hydrazide resulting from the reaction with the Girard's reagent T and Schiff bases with polyamines. The condensation between the two aldehyde groups and cadaverine, putrescine or spermidine gives macrocyclic bridged products. A disubstituted non cyclic derivative is obtained with an excess of cadaverine. These products are of biological interest.


Assuntos
Gossipol/análogos & derivados , Gossipol/síntese química , Gossipol/farmacologia , Poliaminas/metabolismo , Bases de Schiff/síntese química
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