RESUMO
OBJECTIVES: To estimate the probability of survival and to evaluate risk factors for death in a cohort of persons living with human immunodeficiency virus (PLHIV) who had started tuberculosis (TB) treatment. METHODS: A prospective cohort study was conducted between June 2007 and December 2009 with HIV-infected patients who had started anti-tuberculosis treatment in the State of Pernambuco, Brazil. Survival data were analysed using the Kaplan-Meier estimator, the log-rank test and the Cox model. Hazard ratios and their respective 95%CIs were estimated. RESULTS: Of a cohort of 2310 HIV-positive individuals, 333 patients who had commenced treatment for TB were analysed. The mortality rate was 5.25 per 10,000 person-years (95%CI 4.15-6.63). The probability of survival at 30 months was 74%. Risk factors for death in the study population were being female, age ≥30 years, having anaemia, not using highly active antiretroviral therapy (HAART) during treatment for TB and disseminated TB. Protective factors for death were a CD4 lymphocyte count >200 cells/mm(3) and treatment for TB having started in an out-patient clinic. CONCLUSIONS: The use of HAART can prevent deaths among HIV-TB patients, corroborating the efficacy of starting HAART early in individuals with TB.
Assuntos
Terapia Antirretroviral de Alta Atividade/métodos , Infecções por HIV/mortalidade , Tuberculose/mortalidade , Adolescente , Adulto , Idoso , Anemia/epidemiologia , Anemia/etiologia , Antituberculosos/uso terapêutico , Brasil/epidemiologia , Contagem de Linfócito CD4 , Estudos de Coortes , Feminino , Infecções por HIV/tratamento farmacológico , Infecções por HIV/epidemiologia , Humanos , Estimativa de Kaplan-Meier , Masculino , Pessoa de Meia-Idade , Modelos de Riscos Proporcionais , Estudos Prospectivos , Fatores de Risco , Fatores Sexuais , Análise de Sobrevida , Taxa de Sobrevida , Tuberculose/tratamento farmacológico , Tuberculose/epidemiologia , Adulto JovemRESUMO
Avalia e aplica métodos estatísticos aos dados do Sistema de Vigilância da aids no Brasil. É composta de quatro artigos: o primeiro apresenta casos notificados até o primeiro semestre de 1996; o segundo compara estimativas por categoria de exposição; o terceiro desenvolve um modelo não estacionário e o quarto métodos de cálculo retroativo
