[Intravitreal Bevacizumab injections in a child with choroidal neovascularization--case report]. / Iniekcje doszklistkowe bevacizumabu u dziecka z podsiatkówkowa neowaskularyzacja--opis przypadku.

A healthy 11 year old boy with active choroidal neovascularization (CNV) was referred to the Department of Ophthalmology in Wroclaw for unilateral visual deterioration from 2 weeks. The best-corrected visual acuity was counting fingers from 4 meters. Boy was successfully treated with three intravitreal injections of bevacizumab. Intravitreal bevacizumab was well tolerated, choroidal neovascularization involuted, and best-corrected visual acuity improved to 20/32. The boy remained stable for 6 months after injections.

[Idiopathic choroidal neovascularization in children]. / Idiopatyczna neowaskularyzacja podsiatkówkowa u dzieci.

Idiopathic choroidal neovascularization (CNV) in children is a rare, but important cause of visual impairment. Purpose of this paper is to report one year clinical observation of 4 children with idiopathic choroidal neovascularization. Authors present 4 cases of CNV in boys at 6-13 years old, with unilateral visual deterioration onset. All cases were diagnosed as idiopathic ones after pediatric and ophthalmological examination including fundus color photographs and optical coherence tomography (OCT) in all cases, fluorescein angiography (FA) in 2 cases, as well as laboratory tests to exclude the systemic diseases. All cases were left untreated. This presentation discusses therapeutic management according to the argon laser therapy, photodynamic therapy, submacular surgery and intravitreal injection of anti-VEGF.

[Analysis of rate, types and causes of uveitis in children hospitalized at Ophthalmology Clinic in Wroclaw in years 2001-2006]. / Analiza czestosci wystepowania zapalenia blony naczyniowej, jego rodzajów i przyczyn powstawania u dzieci hospitalizowanych w Klinice Okulistyki we Wroclawiu w latach 2001-2006.

PURPOSE: The aim of the paper was to analyse frequency, causes and type of uveitis at children hospitalized in Ophthalmology Clinic of Medical Academy in Wroclaw in years 2001-2006. MATERIALS AND METHODS: Material from 64 (88 pairs) children's eyes was analyzed. There were 35 (54.7%) girls and 29 (45.3%) boys admitted to the Clinic with suspicion of uveitis. RESULTS: There were 17 (26.6%) children with uveitis anterior, 15 (23.4%) with pars planitis and 32 (50.0%) with uveitis posterior. The uveitis occurred in both eyes in 33.9%. Aetiology of uveitis was recognized at 30 (46.9%) patients, at 12 (16.6%) cases uveitis was related to systemic disease. At 22 (34.4%) ill children recognition of aetiology was not possible. The most often cause of uveitis anterior was juvenile chronic arthrosis inflammation and it occurred at 8 (47.1%) children--5 girls, and 3 boys. For the most patients 12 (80.0%), in case of pars planitis recognition of aetiology was impossible. Toxoplasmosis was the most often cause for uveitis posterior and it occurred at 14 (43.8%) children. CONCLUSIONS: Parasitic background is still considerable cause of uveitis among children. Juvenile chronic arthritis is the most often cause for uveitis anterior. In considerable amount of children cases, recognition of aetiology of uveitis was not possible.

[Estimation of immunological markers in children with intermediate uveitis symptoms]. / Ocena wybranych wykladników odpowiedzi immunologicznej u dzieci z objawami zapalenia czesci posredniej blony naczyniowej.

PURPOSE: The purpose of this study was to estimate markers of immunological response in the blood of children with intermediate uveitis. MATERIAL AND METHODS: The records of 13 children (26 eyes), aged 10-17 years, with idiopathic intermediate uveitis were reviewed. In all cases indicators of inflammation and immunological response parameters were analyzed during the active stage of the disease. RESULTS: In almost all patients ((90%) with intermediate uveitis disturbances in the level and activity of lymphocyte system, were detected. There were also nonspecific changes in immunoglobulins level in all patients, in 31% in more then one class of immunoglobulins. Chemiluminescence of phagocytic cells were reduced in more than 50% of children, and increase in their phagocytic activity was observed in 62% of patients. Circulating immune complexes were present in 50% of cases. CONCLUSIONS: The study presents data supporting the theory of autoimmunological background of the intermediate uveitis.