RESUMO
BACKGROUND: Recurrent panniculitis in children with lipoatrophy has been loosely described and reported under different names, but has never been systematically evaluated by immunohistochemical stains. OBJECTIVE: To depict the profile of children with recurrent idiopathic panniculitis. METHODS: Study of clinical, histopathological and immunohistochemical features in five cases with recurrent idiopathic panniculitis. RESULTS: Five children with repeated attacks of painful subcutaneous nodules in association with fever, malaise and abdominal pain or arthralgia, with subsequent lipoatrophy were reviewed. In two patients, extensive involvement led to loss of the cutaneous fatty tissue. Laboratory abnormalities included increased acute phase reactants, leukocytosis with mild neutrophilia, microcytic anaemia and elevated liver enzymes. Histopathology showed lobar panniculitis without vasculitis and with a mixed infiltrate, composed of neutrophils, mononuclear cells, lymphocytes, macrophages and myeloid cells. Neutrophils and myeloid cells were more prominent in early lesions, whereas macrophages predominated in late stages, leading to lipophagia and lipoatrophy. Immunohistochemistry showed positive staining for myeloperoxidase around the necrotic adipocytes in early stages and CD68/PGM1 macrophages in late stages. Intense STAT1 staining was observed in the inflammatory infiltrate. All patients improved with methotrexate and corticosteroids. CONCLUSION: We present five cases of lobar panniculitis and lipoatrophy in childhood. The clinico-pathologic presentation shares features with other autoinflammatory diseases.
Assuntos
Tecido Adiposo/química , Tecido Adiposo/patologia , Paniculite/sangue , Paniculite/patologia , Proteínas de Fase Aguda/metabolismo , Adipócitos/química , Anemia/etiologia , Antígenos CD/análise , Antígenos de Diferenciação Mielomonocítica/análise , Atrofia/patologia , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Leucocitose/sangue , Linfócitos , Macrófagos/química , Masculino , Neutrófilos , Paniculite/complicações , Peroxidase/análise , Recidiva , Fator de Transcrição STAT1/análiseRESUMO
Interferon is used to treat hepatitis C virus infection and its cutaneous side effects are well known. Recently, interferon-induced sarcoidosis has been reported. We report a new case of sarcoidosis during pegylated interferon alfa and ribavirin treatment with an unusual presentation in a woman with previous episodes of erythema nodusum and nodular vasculitis related to HCV.
Assuntos
Hipopigmentação/patologia , Adolescente , Adulto , Progressão da Doença , Feminino , Humanos , Adulto JovemRESUMO
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Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Febre por Mordedura de Rato/diagnóstico , Streptobacillus/patogenicidade , Spirillum/patogenicidade , Espanha/epidemiologiaAssuntos
Desfibriladores Implantáveis/efeitos adversos , Eritema/etiologia , Complicações Pós-Operatórias/etiologia , Telangiectasia/etiologia , Idoso , Aneurisma da Aorta Abdominal/complicações , Aneurisma da Aorta Abdominal/cirurgia , Berílio/efeitos adversos , Eritema/patologia , Humanos , Masculino , Complicações Pós-Operatórias/patologia , Remissão Espontânea , Taquicardia Ventricular/complicações , Taquicardia Ventricular/cirurgia , Telangiectasia/patologia , Timerosal/efeitos adversosAssuntos
Ceratose/etiologia , Tuberculose Cutânea/diagnóstico , Alcoolismo/complicações , Antituberculosos/uso terapêutico , Discite/complicações , Discite/diagnóstico por imagem , Discite/cirurgia , Cotovelo , Humanos , Ceratose/microbiologia , Ceratose/patologia , Laminectomia , Vértebras Lombares , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Mycobacterium tuberculosis/isolamento & purificação , Radiografia , Fusão Vertebral , Tuberculoma/diagnóstico por imagem , Tuberculose Cutânea/tratamento farmacológico , Tuberculose Cutânea/microbiologia , Tuberculose Cutânea/patologia , Tuberculose Pulmonar/complicações , Tuberculose Pulmonar/diagnóstico por imagem , Tuberculose da Coluna Vertebral/complicações , Tuberculose da Coluna Vertebral/diagnóstico por imagem , Tuberculose da Coluna Vertebral/cirurgiaRESUMO
The fatty acid methyl ester (FAME) profiles of "Pasteurella" piscicida were determined by gas chromatography and subjected to numerical analysis in comparison with those obtained for Vibrio anguillarum, Aeromonas salmonicida and Pasteurella species of clinical origin. The bacterial species studied shared important characteristics with respect to their FAME content: in all of them the saturated and unsaturated fatty acids of 16 carbon atoms were the predominant fatty acids. However, distinguishing features could be detected for each pathogen. Using either single linkage or complete linkage algorithms, strains were divided into four phena that corresponded to the different species, but showed a high degree of correlation among them. Although single linkage discriminated strains better within each phenum, complete linkage was more useful to establish the relationships among clusters. The results obtained support the idea that "Pasteurella" piscicida is related to members of the genera Vibrio and Aeromonas and indicate the need for exhaustive genetic studies to clarify the taxonomic position of this fish pathogen.
