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Int J Immunogenet ; 37(4): 293-8, 2010 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-20518833

RESUMO

Cytokines are crucial for the regulation of inflammation development in humans. Many studies have shown that variations in cytokine genes might play a role in determining human longevity. This study examined the changes in the gene pool relevant to the -308 G/A polymorphism in the promoter region of the proinflammatory cytokine tumour necrosis factor (TNF)-alpha gene and the -1082 G/A polymorphism in the promoter region of anti-inflammatory cytokine interleukin (IL)-10 gene with aging and survival selection occurs in the Jordanian population. IL-10 -1028 G/A and TNF-alpha-308 G/A were genotyped in 119 randomly selected elderly subjects (41 women and 78 men) with a mean age of 90.2 years and young control subjects of 118 (46 women and 72 men) with a mean age of 31.9 years. No significant differences were found in the genotype and allele frequencies of TNF-alpha gene variants between the two groups (P > 0.05) while the IL-10 genotype and allele frequencies were significantly associated with longevity in men (P < 0.05) but not in women (P < 0.05). Thus, IL-10 -1028 G/A polymorphism seems to play a role in the pathway to longevity in Jordanian men.


Assuntos
Árabes/genética , Interleucina-10/genética , Longevidade/genética , Polimorfismo de Nucleotídeo Único , Regiões Promotoras Genéticas/genética , Fator de Necrose Tumoral alfa/genética , Adulto , Idoso de 80 Anos ou mais , Alelos , Árabes/estatística & dados numéricos , Feminino , Frequência do Gene , Predisposição Genética para Doença , Genótipo , Humanos , Inflamação/genética , Interleucina-10/fisiologia , Jordânia/epidemiologia , Longevidade/imunologia , Masculino , Polimorfismo de Fragmento de Restrição , Estudos de Amostragem , Fatores Sexuais , Fator de Necrose Tumoral alfa/fisiologia
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