Assuntos
Promoção da Saúde/legislação & jurisprudência , Prevenção do Hábito de Fumar , Abandono do Uso de Tabaco , Publicidade/legislação & jurisprudência , Comparação Transcultural , Humanos , Nova Zelândia , Fumar/efeitos adversos , Fumar/legislação & jurisprudência , Impostos/legislação & jurisprudência , Poluição por Fumaça de Tabaco/legislação & jurisprudência , Poluição por Fumaça de Tabaco/prevenção & controle , Estados UnidosRESUMO
Fifty-eight dogs with lymphoma were treated with combination chemotherapy (vincristine, cyclophosphamide, L-asparaginase, and doxorubicin HCl [VCAA]) followed by intralymphatic autochthonous tumor cell vaccine (CI). Thirty dogs received chemotherapy alone (VCAA). There was no overall significant difference in survival times between the two groups, although there was a trend toward prolonged survival in the CI group. Asymptomatic dogs (Stage A) and dogs less than 7 years of age with Stage A disease treated with CI had significantly longer survival. Dogs treated with CI had a significantly longer first remission. Regardless of treatment group, male dogs had significantly longer remission times compared with female dogs.
Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Doenças do Cão/terapia , Imunoterapia , Linfoma/veterinária , Fatores Etários , Animais , Asparaginase/administração & dosagem , Terapia Combinada , Ciclofosfamida/administração & dosagem , Doenças do Cão/tratamento farmacológico , Cães , Doxorrubicina/administração & dosagem , Combinação de Medicamentos/administração & dosagem , Estudos de Avaliação como Assunto , Feminino , Injeções Intralinfáticas , Linfoma/tratamento farmacológico , Linfoma/imunologia , Linfoma/terapia , Masculino , Indução de Remissão , Vacinas/administração & dosagem , Vincristina/administração & dosagemRESUMO
Canine lymphoma is analogous to non-Hodgkin's lymphoma and is responsive to similar cytotoxic agents. The purpose of this study was to investigate a tumor cell vaccine delivered via peripheral lymphatics as maintenance therapy after induction of remission with chemotherapy. Thirty dogs with histologically confirmed lymphoma were treated with chemoimmunotherapy, and were induced into remission with combination chemotherapy, followed by intralymphatic (IL) autochthonous tumor cell vaccines as maintenance therapy. All dogs received two cycles of chemotherapy and at least three vaccine infusions. The median survival was 13 months with 11/30 (36%) still alive at 1-3 years follow-up. The median remission duration was 16 weeks while on IL vaccines alone. The survival time and remission duration is longer than previously reported in canine lymphoma.
