1.
Org Biomol Chem
; 8(13): 2941-55, 2010 Jun 28.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20442913
RESUMO
Azide- and alkynyl-containing homo-beta(3)-peptides, of up to six residues in length, were synthesised in solution from aspartic acid. Their subsequent conjugation with monosaccharides bearing an azide or a terminal alkyne function was efficiently achieved by copper-mediated cycloadditions leading to two novel families of small glycoclusters. These compounds represent ideal tools to explore carbohydrate-mediated multivalent interactions.