Jugando con la futura visión. Neovascularización coroidea por puntero láser / Playing with future sight. Choroidal neovascularisation due to hand-held laser pointers

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Alternativa terapéutica para el retinoblastoma: quimioterapia intraarterial con melfalán / Alternative treatment for retinoblastoma: Intra-arterial chemotherapy with melphalan

CASO CLÍNICO: Un lactante de 10 meses fue remitido para estudio de leucocoria izquierda de un mes de evolución. En la exploración se detectó un retinoblastoma que ocupaba el área macular. Fue tratado con quimioterapia intraarterial con 6 mg de melfalán, sin requirir posteriores intervenciones para el control de la enfermedad. DISCUSIÓN: El melfalán es un agente quimioterápico muy efectivo, con uso limitado por la toxicidad sistémica que genera. La quimioterapia intraarterial permite la liberación selectiva en la arteria oftálmica, lo que limita la toxicidad sistémica. Esta combinación de eficacia, seguridad y precisión la hacen una alterativa terapéutica atractiva para el manejo del retinoblastoma

CASE REPORT: A 10-month old infant was referred for the study of a leukocoria of the left eye of one month onset. On examination, a retinoblastoma occupying the macular area was detected. Treatment with intra-arterial chemotherapy (melphalan 6 mg) was performed, with no further intervention required for disease control. DISCUSSION: Melphalan is an effective chemotherapeutic agent. However, its use is limited by the systemic toxicity that may occur. Intra-arterial chemotherapy allows the selective release of melphalan into the ophthalmic artery, thus limiting its systemic toxicity. This combination of efficiency, safety and accuracy makes it an attractive therapeutic alternative for the management of retinoblastoma

Alternative treatment for retinoblastoma: Intra-arterial chemotherapy with melphalan.

CASE REPORT: A 10-month old infant was referred for the study of a leukocoria of the left eye of one month onset. On examination, a retinoblastoma occupying the macular area was detected. Treatment with intra-arterial chemotherapy (melphalan 6 mg) was performed, with no further intervention required for disease control. DISCUSSION: Melphalan is an effective chemotherapeutic agent. However, its use is limited by the systemic toxicity that may occur. Intra-arterial chemotherapy allows the selective release of melphalan into the ophthalmic artery, thus limiting its systemic toxicity. This combination of efficiency, safety and accuracy makes it an attractive therapeutic alternative for the management of retinoblastoma.

Lack of acute pathogenicity and toxicity in mice of an isolate of Metarhizium anisopliae var. anisopliae from spittlebugs.

A monospore strain of Metarhizium anisopliae var. anisopliae (EH-479/2), isolated in Mexico from Aeneolamia sp., was tested for oral acute intragastric pathogenicity and toxicity in CD-1 mice, including a thorough histological study. Animals were inoculated by gavage with one dose (10(8) conidia/animal) of viable (72 mice) and nonviable (24 mice) conidia and compared to 18 control mice. Clinical observations were done daily; mycological and histological tests were performed during necropsies at days 3, 10, 17, and 21 after the inoculation. At the end of the study, no mice showed clinical symptoms of illness, and the animals' mean weight corresponded to that of healthy adults. No inflammatory reactions were identified in analyzed organs, suggesting the nonimmunogenic status of this fungal strain. Evidence of fungal germination was noted in two lymph nodes and in liver and lung of one dead mouse, out of 72 viable-conidia treated mice. There was no evidence of toxicity symptoms in mice inoculated with nonviable conidia. The results obtained support the nonpathogenic and nontoxic status of this fungal strain when administered in a sole intragastric dose in mice.