RESUMO
Giant basal cell carcinomas (GBCCs) are a strange and aggressive variety of basal cell carcinomas (BCCs); they are characterized by deep tissue invasion, rapid growth, high risk of metastasis, and a poor prognosis. GBCCs represent 0.4%-1% of all BCCs. The pathogenesis of GBCC is sometimes linked to a spontaneous mutation in the PTCH gene, mapped to the q22.33 locus of chromosome 9. The key factor in the development of GBCC, in at least 30% of the cases, is the delay in seeking medical attention (7.5 ± 3.1 years). This is associated to a poor socioeconomic level, deficient hygiene, mental illness, advanced age, and the fact that BCCs are painless lesions. The authors present a Mexican female with a 2-year ulcer diagnosed as a GBCC in the year 2000, its initial therapeutic approach, and her follow-up during the next 12 years.
Assuntos
Carcinoma Basocelular/complicações , Neoplasias Faciais/complicações , Recidiva Local de Neoplasia/complicações , Neoplasias Cutâneas/complicações , Úlcera Cutânea/etiologia , Adulto , Carcinoma Basocelular/patologia , Progressão da Doença , Enucleação Ocular , Face , Neoplasias Faciais/patologia , Feminino , Seguimentos , Humanos , Deformidades Adquiridas Nasais/etiologia , Neoplasias Cutâneas/patologiaRESUMO
Colorectal cancer is an important neoplasm in general population, about 90% of the cases are sporadical, but near of 5% are due to hereditary non polyposis colorectal cancer. Early detection is imperative due to genetic linkage and association to other neoplasms diagnosed an early age. This case report is about a young man diagnosed with colorectal cancer that presented multiple recurrences and had at least two affected generations. The most important aspects of diagnosis, management and genetic counseling are discussed.
