Assuntos
Polipose Adenomatosa do Colo/diagnóstico , Hipopigmentação/diagnóstico , Espinha Bífida Oculta/diagnóstico , Abscesso/microbiologia , Abscesso/terapia , Polipose Adenomatosa do Colo/cirurgia , Adolescente , Fadiga/etiologia , Hemorragia Gastrointestinal/etiologia , Humanos , Lactente , Masculino , Transtornos dos Movimentos/etiologia , Transtornos dos Movimentos/terapia , Reto , Espinha Bífida Oculta/terapiaAssuntos
Abscesso/diagnóstico , Síndrome de Klippel-Trenaunay-Weber/diagnóstico , Osteomielite/diagnóstico , Pediatria/métodos , Infecções por Salmonella/diagnóstico , Sinusite/diagnóstico , Abscesso/etiologia , Abscesso/terapia , Adolescente , Dor nas Costas/etiologia , Dor nas Costas/terapia , Diagnóstico Diferencial , Feminino , Humanos , Recém-Nascido , Síndrome de Klippel-Trenaunay-Weber/terapia , Vértebras Lombares , Masculino , Osteomielite/complicações , Osteomielite/terapia , Mancha Vinho do Porto/diagnóstico , Infecções por Salmonella/complicações , Infecções por Salmonella/terapia , Couro Cabeludo , Sinusite/complicações , Sinusite/terapiaAssuntos
Acalasia Esofágica/diagnóstico , Insulinoma/diagnóstico , Malária/diagnóstico , Neoplasias Pancreáticas/diagnóstico , Criança , Diagnóstico Diferencial , Acalasia Esofágica/terapia , Feminino , Humanos , Hiperinsulinismo/etiologia , Hiperinsulinismo/terapia , Hipoglicemia/etiologia , Lactente , Masculino , Convulsões/etiologiaRESUMO
Hypofractionated chest radiotherapy has been used as an alternative when standard fractionated schedules are neither practical nor feasible. To explore docetaxel as radiosensitizer in a hypofractionated chest irradiation schedule, a docetaxel dose escalation study was conducted in which 26 patients with advanced non-small-cell lung cancer (NSCLC) (stages III and IV) were enrolled. Docetaxel was administered 24 hours prior to irradiation (starting dose 10mg/m2; escalating in 5mg/m2 increments). Radiation was administered at 500 cGy (one fraction) once/wk for 10 consecutive weeks (5000 cGy total). The docetaxel dose was escalated up to 45 mg/m2/wk. The treatment was well tolerated over 10 consecutive weeks without requiring dose reductions or interruptions. Toxicities were mainly docetaxel related. One of 19 evaluable patients had a complete radiographic response within the radiation treatment port, 13 had a partial response, and 5 had stable disease. No patient recurred within the radiation field. Three patients who underwent surgical resection following treatment were pathologically down staged to stage I. This trial of a small group of patients supports, in selected patients, synchronous administration of effective hypofractionated, radiosensitized radiation therapy and optimized systemic chemotherapy.