1.
Drug Metab Dispos
; 11(5): 507-8, 1983.
Artigo
em Inglês
| MEDLINE
| ID: mdl-6138239
2.
Biochem Pharmacol
; 31(18): 2949-54, 1982 Sep 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-6958263
RESUMO
The 100,000 g supernatant fraction of rat liver homogenate contains a sulfotransferase activity which catalyzes the sulfation of minoxidil. Synthetic minoxidil N-O sulfate and the enzyme synthesized product had identical chromatographic characteristics on high pressure liquid chromatography. Minoxidil sulfate, which yields minoxidil when treated with sulfatase, was slowly hydrolyzed in water. Several N-oxides of other heterocycles, including several other pyrimidines, triazines and imidazoles, were also substrates for this sulfotransferase.