RESUMO
Occupational lead poisoning and environmental contamination were evaluated at a lead scrap smelter. Thirty of 37 employees (81 per cent) has blood lead levels of greater than or equal to 80 mug/100 ml, indicating unacceptable absorption, and 35 had free erythrocyte protoporphyrin (FEP) levels greater than 60mug/100ml rbc, indicating toxicity of lead on heme metabolism in red blood cells; eight current and previous employees had been hospitalized with lead colic, and another with encephalopathy. Levels of lead in surface soil (1,800 ppm) and vegetation (20,000 ppm) at the smelter were high and decreased with distance. Animals on nearby pasture had died, and lead levels in the blood, milk, and hair of large and small animals were elevated. Adults living within 100 meters of the smelter had higher blood and hair lead levels than controls, who lived at greater distances, but there was no evidence in them of lead toxicity.
Assuntos
Doenças dos Animais/induzido quimicamente , Poluentes Ambientais/análise , Intoxicação por Chumbo/etiologia , Metalurgia , Alabama , Animais , Doenças do Gato/induzido quimicamente , Gatos , Bovinos , Doenças dos Bovinos/induzido quimicamente , Doenças do Cão/induzido quimicamente , Cães , Exposição Ambiental , Eritrócitos/análise , Cabelo/análise , Hemoglobinas/análise , Doenças dos Cavalos/induzido quimicamente , Cavalos , Humanos , Chumbo/análise , Chumbo/sangue , Intoxicação por Chumbo/sangue , Intoxicação por Chumbo/veterinária , Leite/análise , Protoporfirinas/sangueRESUMO
Tetrachlorodibenzodioxin was identified as the apparent cause of an outbreak of poisoning in humans, horses, and other animals. Exposure was related to the spraying of contaminated waste oil on riding arenas for dust control. The contamination resulted from improper disposal of a toxic industrial waste. The pathologic effects and chemical identification of tetrachlorodibenzodioxin are described.
Assuntos
Dioxinas/intoxicação , Doenças dos Cavalos/induzido quimicamente , Dibenzodioxinas Policloradas/intoxicação , Idoso , Animais , Indústria Química , Criança , Exposição Ambiental , Feminino , Cavalos , Humanos , Resíduos Industriais , Óleos , Dibenzodioxinas Policloradas/toxicidade , Coelhos , Eliminação de Resíduos LíquidosRESUMO
To investigate the relation between low-level absorption and neuropsychological function, blind evaluations were under-taken in forty-six symptom-free children aged 3-15 years with blood-lead concentrations of 40-68 mug. per 100 ml. (mean 48 mug. per 100 ml.) and in seventy-eight ethnically and socioeconomically similar controls with levels greater than mug. per 100 ml. (mean 27 mug. per (100 ml). All children lived within 6-6 km. of a large, lead-emitting smelter, and in many cases residence there had been lifelong. Mean age in the lead group was 8-3 years and in the controls 9-3. Testing with Wechsler intelligence scales for schoolchildren and preschool children (W.I.S.C. and W.P.P.S.I.) showed age-adjusted performance I.Q. to be significantly decreased in the group with higher lead levels (mean scores, W.I.S.C. plus W.P.P.S.I., 95 v. 103). Children in all ages in the lead group also had significant slowing in a finger-wrist tapping test. Full-scale I.Q., verbal I.Q., BEHAVIOUR, AND HYPERACTIVITY RATINGS DID NOT DIFFER.
Assuntos
Transtornos Cognitivos/induzido quimicamente , Intoxicação por Chumbo/complicações , Chumbo/sangue , Destreza Motora , Doenças do Sistema Nervoso/induzido quimicamente , Transtornos da Percepção/induzido quimicamente , Absorção , Adolescente , Sintomas Afetivos/diagnóstico , Fatores Etários , Criança , Pré-Escolar , Cólica/induzido quimicamente , Cólica/diagnóstico , Exposição Ambiental , Humanos , Hipercinese/diagnóstico , Doenças do Sistema Nervoso/diagnóstico , Exame Neurológico , Manifestações Neurológicas , Pica/induzido quimicamente , Pica/diagnóstico , Convulsões/diagnóstico , Fatores Socioeconômicos , Texas , Escalas de WechslerRESUMO
Blood lead levels were determined on a random sample of persons in all age groups living near a lead-emitting smelter in El Paso, Texas. A blood lead level of greater than or equal to 40 mug per 100 ml, which was considered indicative of undue lead absorption, was found in 53 per cent of the children one to nine years old living within 1.6 km of the smelter and in 18 per cent of those from 1.6 to 6.6 km; beyond that distance in older persons levels were lower. Children in the first 1.6 km with blood levels of greater than or equal to mug per 100 ml were exposed to 3.1 times as much lead in dust as children there with lower blood values (6447 vs 2067 ppm). There was also airborne lead exposure (8 to 10 mug per cubic meter, annual mean). Paint, water, food, and pottery were less important as sources. The data suggest that particulate lead in dust and air accounted for most of the lead absorption in El Paso children. The smelter was the principal source of this lead, especially within 1.6km of itself.
Assuntos
Poluentes Atmosféricos/análise , Resíduos Industriais/análise , Chumbo/sangue , Adulto , Ar/análise , Criança , Pré-Escolar , Utensílios de Alimentação e Culinária , Poeira/análise , Exposição Ambiental , Humanos , Lactente , Mineração , Solo/análise , Texas , Abastecimento de Água/análiseAssuntos
Antissepsia , Hexaclorofeno/sangue , Salas Cirúrgicas , Recursos Humanos em Hospital , Cromatografia Gasosa , Detergentes , Feminino , Humanos , Masculino , SabõesAssuntos
Doenças Transmitidas por Alimentos/genética , Carne , Intoxicação por Mercúrio/genética , Adolescente , Adulto , Amniocentese , Ração Animal , Ataxia/induzido quimicamente , Cerebelo/efeitos dos fármacos , Criança , Pré-Escolar , Coma/induzido quimicamente , Dimercaprol/administração & dosagem , Surtos de Doenças , Grão Comestível , Manifestações Oculares , Feminino , Humanos , Injeções Intramusculares , Masculino , Mercúrio/urina , Intoxicação por Mercúrio/tratamento farmacológico , Pessoa de Meia-Idade , New Mexico , Penicilamina/administração & dosagem , Gravidez , Complicações na GravidezAssuntos
Tecido Adiposo/análise , Química Encefálica , DDT/análise , Genitália/análise , Rim/análise , Fígado/análise , Ração Animal , Animais , Animais Recém-Nascidos , DDT/administração & dosagem , DDT/farmacologia , Feminino , Feto/efeitos dos fármacos , Masculino , Troca Materno-Fetal/efeitos dos fármacos , Camundongos , Camundongos Endogâmicos , GravidezRESUMO
Atomic absorption spectrophotometry and neutron activation analysis showed the presence of mercury in organic extracts of seed grain and in tissues of hogs fed the contaminated grain. Mercury was also found in the urine, serum, and cerebrospinal fluid of humans who ate the contaminated pork. Mass spectral analysis confirmed the presence of organic mercury. This paper reports the first documented episode of indirect mercury poisoning in humans in the United States caused by the ingestion of contaminated meat from animals that had consumed mercury in their food supply.
