[Importance of toxicological studies in animals for elaboration of pathogenetic therapy of hydrazine intoxication]. / Znachenie toksikologicheskikh issledovanii na zhivotnykh dlia razrabotki patogeneticheskoi terapii intoksikatsii gidrazinami.

Pathogenesis of poisoning with hydrazine seems complicated. Hydrazines inhibit pyridoxal-dependent enzymes, interfere with carbohydrates transformation and lipid metabolism, alter the processes of energy metabolism. Treatment of poisoning with hydrazine is effective only when containing drug combinations. Based experimentally, recommendations on the combination (phenazepam, be methyl, piracetam, ionol) were supported by chemical testing of the drugs.

[Effect of cholinergic preparations on leukocyte migration]. / Vliianie kholinergicheskikh preparatov na migratsionnuiu aktivnost' leikotsitov.

Study into migration activity of leukocytes in vitro allowed a conclusion that the inhibitors of cholinesterase, armin, takrin and galanthamine, decrease this function. Low doses of atropine stimulate whereas high ones inhibit the migration of leukocytes. Atropine and armin act like antagonists as regards the action on the biological parameter in question: an adverse action of armin can be prevented by atropine.

[Effect of 1,4-benzodiazepine derivatives on the toxic action of oxygen under increased pressure]. / Vliianie proizvodnykh 1,4-benzodiazepina na toksicheskoe deistvie kisloroda pod povyshennym davleniem

The 1,4-benzodiazepine derivatives (diazepam, nitrazepm, lorazepam, clonazepam and two newly synthetized compounds of this series) increase the resistance of albino rats and rabbits to the toxic effect of oxygen under high pressure (7 and 5.5 atm respectively). The compounds under study are apt to avert over a long period the development of metabolic acidosis which appears following the action of high-pressure oxygen on the body.