[Efficiency and safety of generic Atorvastatine in patients at high cardiovascular risk].

Statines are first choice medications for hypercholesterolemia and combined hyperlipidemia of varying severity in wide population of patients. Atorvastatine is one of the most effective statines. In Russia, Atorvastatine is represented by nearly twenty drugs most of which are generics. The article covers data on efficiency, safety and good tolerance of Liptonorm--a generic Atorvastatine.

[Use of Verapamil and Dilthiasem in treating patients at high cardiovascular risk (review of literature)].

The article deals with usage of nondihydropiridine calcium antagonists--verapamil and dilthiasem--in treating patients with arterial hypertension, cardiomyopathy and arrhythmia, for secondary prevention of IHD. Data also concern cardio-, angio--and nephroprotective activity of the medications, their ability to prevent left ventricle hypertrophy, possible usage in patients after myocardial infarction. The authors also discuss problems of tolerance and safety of calcium antagonists with prolonged action vs. those with short-term action.

Optimization of therapeutic teaching of patients with chronic cardiac failure.

The study was aimed to evaluate treatment efficiency of patients with chronic cardiac failure via therapeutic teaching. The study included 137 patients. Implementation of therapeutic teaching into treatment of chronic cardiac failure patients resulted in less number of patients with III-functional grade, better tolerance to physical exertion, more awareness, greater number of patients with self-control skills and adherence to recommended treatment, better life quality of the patients. Medical and social significance manifested in less frequent hospitalizations and calls for emergency medical care.

[Unsolved questions of infectious endocarditis prophylaxis in outpatients practice]. / Nereshennye voprosy profilaktiki infektsionnogo éndokardita v ambulatornoi praktike.

AIM: To check practical feasibility of recommendations of prevention of infectious endocarditis (IE) and to provide more accurate figures on the occurrence of valvular lesions in working population. MATERIALS AND METHODS: Subacute IE manifestations have been analysed in 10 patients of a general outpatient clinic. Echocardiograms of 6209 patients under 60 years of age were studied retrospectively. RESULTS: In one-third of the patients IE developed in the presence of streptococcal and staphylococcal infection. In all the cases cardiac valve involvement was stated. In 4 cases changes in the valve were not accompanied my impairment of the valvular function. By echocardiography, valvular structure changes without valvular disease were detected 2.3 times more frequently that valvular disease. Difficulties presenting in outpatient IE prophylaxis are outlined. CONCLUSION: Advances in IE prevention will be achieved if echo-CG becomes a mandatory examination in the program of working population check-up, if early diagnosis of streptococcal ENT infection is made, if physicians of different specialties work as a team.

[Effect of multifactorial sanatorium-based preventive measures on excessive body weight]. / Vozdeistvie meropriiatii mnogofaktornoi sanatornoi profilaktiki na izbytochnuiu massu tela.

The effects of various procedures and behavior patterns on excessive weight loss are demonstrated in males between 40 and 59 years of age in the course of a program carried out on a standard protocol at 15 sanatoria. The best effect was produced where medical recommendations on diet adjustment were followed strictly, as the reduction of caloric intake was more efficient here, as compared to other diets or exercise. Relative preventive effect was higher, after the same preventive procedures, in individuals with marginal obesity, as compared to those with marked obesity.

[Multi-factor prevention in sanatoria: its effect on increased arterial pressure]. / Mnogofaktornaia profilaktika v sanatoriiakh: vliianie na povyshennoe AD.

Multifactor prophylaxis of CHD and arterial hypertension was tried in 12 sanatoria in 1982 in the population of men aged 40 to 59 with initial arterial hypertension using a unified method. A significant hypotensive effect was achieved, mainly at the expense of the fact of rest itself under sanatorium conditions as a factor of isolation from stresses of everyday life. A raised level of physical activity played the most important role in preventive measures enhancing this effect.

[Prognosis of complex ventricular arrhythmias at different periods in myocardial infarct]. / Prognozirovanie slozhnykh zheludochkovykh aritmii v razlichnye periody infarkta miokarda.

The incidence and pattern of ventricular arrhythmias in acute, subacute, late hospital and posthospital periods of myocardial infarction were investigated, using Holter monitoring, in 121 patients with large-focal and transmural myocardial infarction. A high incidence of complex ventricular arrhythmias was noted after the transfer from intensive care unit (38.8%). The relationship of complex ventricular arrhythmias to ventricular arrhythmias at previous stages was reviewed. Factors contributing to arrhythmias at different stages of myocardial infarction were analysed; the informative value of clinical signs and electric myocardial instability parameters was assessed. Signs having the greatest predictive power were identified, and risk indices for the development of arrhythmias during the subacute and late hospital stages of myocardial infarction were established using linear discriminant analysis, to enable identification of patients at risk of developing ventricular arrhythmias.