[The social economic aspects of disability resulted from diseases of peripheral nervous system].

The diseases of peripheral nervous system (PNS diseases) are diagnosed in 48%-72% of workers in various branches of economy. They made up more than half of all occupational diseases and are the main cause of labor ability and of high level of disability able-bodied population. The purpose of the study is to assess social economic importance of disability because of PNS diseases of able-bodied population in the Republic of Bashkortostan. It is established that in 2014-2018 about 107 individuals of able-bodied age for the first time became disabled because of PNS diseases. The average annual level of individuals of able-bodied age with for the first time established disabilities because of PNS diseases made up to 0.1 cases per 10 thousand of population. Among the disabled 69.0 ± 5.4% are males. The disability rate in males (0.142o/ooo) is twice higher than in females (0.063o/ooo). The average age of the disabled is 48.7 ± 5.7 years. In the structure of disability dominate lumbosacral radiculopathy (50.9%), polyneuropathy of upper (15.3%) and lower (13.5%) extremities. In average, the disability develops in 11.3 years prior to age of 60 years and on 3.8-5.5 years earlier than in case of other diseases. The disability because of PNS diseases shortens healthy life expectancy by 16.0% in males and by 17.8% in females. Annual economic losses come to more than 26 million rubles of non-produced production. The disability because of PNS consists significant social economic problem of society and requires increased attention to prevention, early diagnostics, treatment, improvement of quality of medical social expertise, rehabilitation and habilitation.

[Clinically safe level of dioxines].

Association analysis of various serum levels of dioxines with health parameters revealed that primary molecular, biochemical, functional changes in healthy people appear at the levels of 30 pg/g of serum lipids.

[Criteria of ecologic safety for serum levels of heavy metals in humans].

To evaluate ecologically allowable level of serum metals content in humans for making regional background normal level, the number of heavy metal ions should be determined in healthy human serum and simultaneously homeostasis parameters (hemolysis, biochemistry, immunologic) should be measured--clinically normal limits of these parameters are responsible for safe levels of of the heavy metals in human body. The suggested levels of metals in healthy human serum could serve as clinical MACs.

[Occupational risk and evaluation of health damage in workers engaged in organochlorine compound production]. / Professional'nyi risk i otsenka ushcherba zdorov'iu u rabochikh khlororganicheskogo proizvodstva.

The authors analysed structure and degree of occupational risk in chlorine organic compounds production, revealed a combination of chemical, physical hazards with work burden and determined the work conditions as harmful and dangerous (3.2-3.4). With consideration of most medical and biologic parameters, high level of occupational risk appeared to correspond to significant (from medium to nearly complete) occupational conditionality of the disorders diagnosed. The suggested and approved method to determine occupational conditionality of health disorders at hazardous work conditions could serve as a basis for occupational medical standard.

[Medical and biological aspects of the dioxin problem]. / Mediko-biologicheskie aspekty dioksinovoi problemy.

The article deals with the problem of dioxidine and similar chemicals influencing unfavorable ecologic situation in the world. The authors briefly describe medical and biologic aspects of the problem, demonstrating the present data accumulated mostly by foreign authors and associated primarily with experiments on animals. The information connected with humans appears to be limited, and all researchers have no universal opinion on dioxidine's degree of jeopardy for humans. Scientists of Ufa Research Center for Human Ecology and Occupational Medicine collected unique material on changes in health state of workers after the exposure to 2,4,5-T and dioxidine-related disorder as chloracne. The authors define main spheres of research on the problem.