RESUMO
During the period January 2002-December 2004, we assessed 30 sickle-cell anaemia patients admitted to hospital in Al Khobar with vaso-occlusive crisis for levels of antithrombin (AT) III, protein C (PC) and protein S (PS). We also did platelet aggregation studies. Steady state levels were assessed during follow-up and compared with 36 adult controls. Levels of PC, PS and AT III in the control group were significantly higher than in those in vaso-occlusive crisis and those in steady state (P < 0.001). There was a statistically significant difference between controls and patients for all platelet aggregation factors except adrenaline. There was no significant difference between the levels of PC, PS, AT III and platelet aggregation variables in patients in the steady state and in vaso-occlusive crisis.
Assuntos
Anemia Falciforme/sangue , Antitrombina III/metabolismo , Agregação Plaquetária/fisiologia , Proteína C/metabolismo , Proteína S/metabolismo , Doença Aguda , Difosfato de Adenosina/sangue , Adulto , Análise de Variância , Anemia Falciforme/fisiopatologia , Ácido Araquidônico/sangue , Estudos de Casos e Controles , Colágeno/sangue , Epinefrina/sangue , Feminino , Hospitais Universitários , Humanos , Masculino , Admissão do Paciente , Testes de Função Plaquetária , Ristocetina/sangue , Arábia Saudita , Estatísticas não Paramétricas , VasoconstriçãoRESUMO
This study in King Fahd Hospital of the University, Saudi Arabia, assessed the frequency of alloimmunization to red cell antigens in sickle-cell anaemia patients over 1996-2004 in order to evaluate the risk of alloimmunization and identify the most common alloantibodies. A retrospective analysis of the transfusion history and medical records of 350 patients aged 2 to 75 years who had received at least 1 transfusion found that 48 patients had developed alloantibodies (13.7%). The most common alloantibodies detected were: anti-E alone (18.8%), nonspecific (12.5%), inconclusive (12.5%), anti-K (10.4%) and anti-c 3 (6.3%). Some patients had 1 alloantibody, while others more than 1 and even multiple antibodies. Nine patients had a persistent positive direct antiglobulin test.
Assuntos
Anemia Falciforme/terapia , Incompatibilidade de Grupos Sanguíneos/etiologia , Eritrócitos/imunologia , Reação Transfusional , Adulto , Incompatibilidade de Grupos Sanguíneos/sangue , Incompatibilidade de Grupos Sanguíneos/epidemiologia , Incompatibilidade de Grupos Sanguíneos/imunologia , Transfusão de Sangue/métodos , Transfusão de Sangue/normas , Teste de Coombs , Feminino , Necessidades e Demandas de Serviços de Saúde , Teste de Histocompatibilidade , Hospitais Universitários , Humanos , Fatores Imunológicos/sangue , Isoanticorpos/sangue , Masculino , Programas de Rastreamento , Vigilância da População , Prevalência , Estudos Retrospectivos , Fatores de Risco , Arábia Saudita/epidemiologiaRESUMO
This study in King Fahd Hospital of the University, Saudi Arabia, assessed the frequency of alloimmunization to red cell antigens in sickle-cell anaemia patients over 1996-2004 in order to evaluate the risk of alloimmunization and identify the most common alloantibodies. A retrospective analysis of the transfusion history and medical records of 350 patients aged 2 to 75 years who had received at least 1 transfusion found that 48 patients had developed alloantibodies [13.7%]. The most common alloantibodies detected were: anti-E alone [18.8%], nonspecific [12.5%], inconclusive [12.5%], anti-K [10.4%] and anti-c 3 [6.3%]. Some patients had 1 alloantibody, while others more than 1 and even multiple antibodies. Nine patients had a persistent positive direct antiglobulin test
Assuntos
Eritrócitos , Transfusão de Sangue , Isoanticorpos , Anemia FalciformeRESUMO
During the period January 2002- December 2004, we assessed 30 sickle- cell anaemia patients admitted to hospital in Al Khobar with vaso- occlusive crisis for levels of antithrombin [AT] III, protein C [PC] and protein S [PS]. We also did platelet aggregation studies. Steady state levels were assessed during follow- up and compared with 36 adult controls. Levels of PC, PS and AT III in the group were significantly higher than in those in vaso- occlusive crisis and those in steady state control [P < 0.001]. There was a statistically significant difference between controls and patients for all platelet factors except adrenaline. There was no significant difference between the levels of PC, PS, aggregation AT III and platelet aggregation variables in patients in the steady state and in vaso- occlusive crisi
Assuntos
Proteína C , Proteína S , Antitrombina III , Agregação Plaquetária , Anemia FalciformeRESUMO
The prevalence of serological markers of HBV and HCV were determined for blood donors in eastern Saudi Arabia. Between 1998 and 2001, 13,443 donors (10,778 Saudi and 2665 non-Saudi), were screened for HBsAg, anti-HBc Ab, and anti-HCV Ab using commercial kits. There was a steady decrease in the HBsAg (2.58 and 1.67%), anti-HBc rates (15.32 and 9.15%), and anti-HCV (1.04 and 0.59%) rates between 1998 and 2001, respectively. However, there was a marked difference between Saudi and non-Saudi donors with regard to anti-HBc (P < 0.001) and anti-HCV (P < 0.01), but not HBsAg prevalence rates in the same time period.
