Dissociable encoding of motivated behavior by parallel thalamo-striatal projections.

The successful pursuit of goals requires the coordinated execution and termination of actions that lead to positive outcomes. This process relies on motivational states that are guided by internal drivers, such as hunger or fear. However, the mechanisms by which the brain tracks motivational states to shape instrumental actions are not fully understood. The paraventricular nucleus of the thalamus (PVT) is a midline thalamic nucleus that shapes motivated behaviors via its projections to the nucleus accumbens (NAc)1,2,3,4,5,6,7,8 and monitors internal state via interoceptive inputs from the hypothalamus and brainstem.3,9,10,11,12,13,14 Recent studies indicate that the PVT can be subdivided into two major neuronal subpopulations, namely PVTD2(+) and PVTD2(-), which differ in genetic identity, functionality, and anatomical connectivity to other brain regions, including the NAc.4,15,16 In this study, we used fiber photometry to investigate the in vivo dynamics of these two distinct PVT neuronal types in mice performing a foraging-like behavioral task. We discovered that PVTD2(+) and PVTD2(-) neurons encode the execution and termination of goal-oriented actions, respectively. Furthermore, activity in the PVTD2(+) neuronal population mirrored motivation parameters such as vigor and satiety. Similarly, PVTD2(-) neurons also mirrored some of these parameters, but to a much lesser extent. Importantly, these features were largely preserved when activity in PVT projections to the NAc was selectively assessed. Collectively, our results highlight the existence of two parallel thalamo-striatal projections that participate in the dynamic regulation of goal pursuits and provide insight into the mechanisms by which the brain tracks motivational states to shape instrumental actions.

Smallpox Geographies: vaccination, borders and Indigenous peoples in Australia's coastal north.

Australia's approach to its biosecurity and borders has always been two-pronged - quarantine first, vaccination second. This article asks what this combination looked like in practice by exploring two neglected smallpox vaccination campaigns directed towards Indigenous peoples in the early twentieth century. We argue these were important campaigns because they were the first two pre-emptive, rather than reactionary, vaccination programs directed towards First Nations people. Second, both episodes occurred in Australia's northern coastline, where the porous maritime geography and proximity to Southeast Asia posed a point of vulnerability for Australian health officials. While smallpox was never endemic, (though epidemic), in Australia, it was endemic at various times and places across Southeast Asia. This shifting spectre of smallpox along the northern coastline was made even more acute for state and federal health officials because of the existing polyethnic relationships, communities, and economies. By vaccinating Indigenous peoples in this smallpox geography, they were envisioned and embedded into a 'hygienic' border for the protection of white Australia, entwining the two-prongs as one approach. In this article, we place public health into a recent scholarship that has 'turned the map upside down' to re-spatialise Australia's history and geography to the north and its global connections, while demonstrating how particular coastlines and their connections were drawn into a national imaginary through a health lens.

Dissociable encoding of motivated behavior by parallel thalamo-striatal projections.

The successful pursuit of goals requires the coordinated execution and termination of actions that lead to positive outcomes. This process is thought to rely on motivational states that are guided by internal drivers, such as hunger or fear. However, the mechanisms by which the brain tracks motivational states to shape instrumental actions are not fully understood. The paraventricular nucleus of the thalamus (PVT) is a midline thalamic nucleus that shapes motivated behaviors via its projections to the nucleus accumbens (NAc)1-8 and monitors internal state via interoceptive inputs from the hypothalamus and brainstem3,9-14. Recent studies indicate that the PVT can be subdivided into two major neuronal subpopulations, namely PVTD2(+) and PVTD2(-), which differ in genetic identity, functionality, and anatomical connectivity to other brain regions, including the NAc4,15,16. In this study, we used fiber photometry to investigate the in vivo dynamics of these two distinct PVT neuronal types in mice performing a reward foraging-like behavioral task. We discovered that PVTD2(+) and PVTD2(-) neurons encode the execution and termination of goal-oriented actions, respectively. Furthermore, activity in the PVTD2(+) neuronal population mirrored motivation parameters such as vigor and satiety. Similarly, PVTD2(-) neurons, also mirrored some of these parameters but to a much lesser extent. Importantly, these features were largely preserved when activity in PVT projections to the NAc was selectively assessed. Collectively, our results highlight the existence of two parallel thalamo-striatal projections that participate in the dynamic regulation of goal pursuits and provide insight into the mechanisms by which the brain tracks motivational states to shape instrumental actions.

Introduction: modern airs, waters, and places.

Twenty-four centuries have passed since the doctrine of AirsWaters Places was articulated in the Hippocratic corpus, promoting a mutually constitutive vision of humankind and climate. Yet the "airs, waters, places tradition" has proved remarkably resilient and adaptable as a framing device for relations among nations, natural and human resources, and human health. Redeployed in diverse historical contexts across time, the relationship between climate and humans has evolved from a dependent one in which human constitution and health are determined by climate to an interdependent one in which humans and climate influence one another. Recent scholarship extends the ways in which historians of colonial medicine, neo-Hippocratic medicine, public health, tropical disease, and race have characterized the climate-human nexus and its attendant politics. Through the exploration of the works of circumnavigators, physicians, physiologists, ecologists, geographers, paleoanthropologists, and economists, contributors to this special issue offer some new and sometimes challenging interpretations of medical climatology: beyond the link between tropical medicine and colonialism, beyond temperate versus tropical, beyond latitude to think of altitude.

Anticolonial climates: physiology, ecology, and global population, 1920s-1950s.

Historiography on tropical medicine and determinist ideas about climate and racial difference rightly focuses on links with nineteenth- and twentieth-century colonial rule. Occasionally and counterintuitively, however, these ideas have been redeployed as anticolonial argument. This article looks at one such instance; the racial physiology of Indian economist, ecologist, and anticolonial nationalist Radhakamal Mukerjee (1889-1968). It argues that the explanatory context was mid-twentieth-century discussion of global population growth, which raised questions of density and belonging to land. Ecology offered a new language and scientific system within which people and place were conceptually integrated, in this instance to anticolonial ends.

Early outcomes of bilateral sequential single lung transplantation after ex-vivo lung evaluation and reconditioning.

BACKGROUND: Ex vivo lung perfusion (EVLP) is a novel approach for extended evaluation and/or reconditioning of donor lungs not meeting standard International Society for Heart and Lung Transplantation criteria for transplantation. METHODS: We retrospectively evaluated 13 consecutive EVLP runs between January 2009 and December 2010. Lungs rejected for routine transplantation were implanted to the EVLP circuit and reperfused using acellular supplemented Steen Solution (Vitrolife, Göteborg, Sweden) up to a target flow rate of 40% of the donor's calculated flow at a cardiac index of 3.0 liters/min/m(2); target left atrial pressure < 5 mm Hg; and pulmonary artery pressure < 15 mm Hg. Mechanical ventilation was introduced after rewarming to 32°C: tidal volume, 6 to 8 ml/kg; respiratory rate, 7 to 8 breaths/min; duration of inspiration/expiration (I/E) ratio, 1:2; and positive end-expiratory pressure, 5 to 10 cm H(2)O. Hemodynamic and respiratory data monitoring with hourly clinical assessment were performed. Donor data, conversion rate to transplantation, and recipient outcome were analyzed. RESULTS: Donor data (n = 13) were: age, 44.23 ± 8.33 years; female/male, 8:5; cause of death: intracranial hemorrhage, 11 (85%), stroke, 1 (7.5%), hypoxic brain injury, 1 (7.5%); smoking history, 9 (69%), 17.44 ± 8.92 pack-years; mechanical ventilation, 102.6 ± 91.92 hours; chest x-ray imaging: abnormal, 12 (92.5%); normal, 1 (7.5%). EVLP: mean 141 ± 28.83 minutes. Arterial partial pressure of oxygen/fraction of inspired oxygen 100% before termination of the circuit vs pre-retrieval value: 57.32 ± 9.1 vs 42.36 ± 14.13 kPa (p < 0.05). Six (46%) pairs of donor lungs were transplanted. Median follow-up was 297.5 days (range, 100-390 days), with 100% survival at 3 months. CONCLUSIONS: EVLP may facilitate assessment and/or reconditioning of borderline lungs, with a conversion rate of 46 % and good short-term survival.

The Oxford Handbook of The History of Eugenics

Eugenic thought and practice swept the world from the late nineteenth to the mid-twentieth century in a remarkable transnational phenomenon. Eugenics informed social and scientific policy across the political spectrum, from liberal welfare measures in emerging social-democratic states to feminist ambitions for birth control, from public health campaigns to totalitarian dreams of the "perfectibility of man." This book dispels for uninitiated readers the automatic and apparently exclusive link between eugenics and the Holocaust. It is the first world history of eugenics and an indispensable core text for both teaching and research. Eugenics has accumulated generations of interest as experts attempted to connect biology, human capacity, and policy. In the past and the present, eugenics speaks to questions of race, class, gender and sex, evolution, governance, nationalism, disability, and the social implications of science. In the current climate, in which the human genome project, stem cell research, and new reproductive technologies have proven so controversial, the history of eugenics has much to teach us about the relationship between scientific research, technology, and human ethical decision-making.

The Oxford Handbook of The History of Eugenics

Eugenic thought and practice swept the world from the late nineteenth to the mid-twentieth century in a remarkable transnational phenomenon. Eugenics informed social and scientific policy across the political spectrum, from liberal welfare measures in emerging social-democratic states to feminist ambitions for birth control, from public health campaigns to totalitarian dreams of the "perfectibility of man." This book dispels for uninitiated readers the automatic and apparently exclusive link between eugenics and the Holocaust. It is the first world history of eugenics and an indispensable core text for both teaching and research. Eugenics has accumulated generations of interest as experts attempted to connect biology, human capacity, and policy. In the past and the present, eugenics speaks to questions of race, class, gender and sex, evolution, governance, nationalism, disability, and the social implications of science. In the current climate, in which the human genome project, stem cell research, and new reproductive technologies have proven so controversial, the history of eugenics has much to teach us about the relationship between scientific research, technology, and human ethical decision-making(AU)

Thinking historically about public health.

This paper argues that analysing past public health policies calls for scholarship that integrates insights not just from medical history but from a broad range of historical fields. Recent studies of historic infectious disease management make this evident: they confirm that prior practices inhere in current perceptions and policies, which, like their antecedents, unfold amidst shifting amalgams of politics, culture, law and economics. Thus, explaining public health policy of the past purely in medical or epidemiological terms ignores evidence that it was rarely, if ever, designed solely on medical grounds at the time.

At the border: contagion, immigration, nation.

In recent publications and as an ongoing project I have been pursuing the idea that public health and infectious disease control have been part of the legal and technical constitution of 'undesirable' and prohibited entrants: an under-recognised means by which individuals and certain populations have been specifically classified and excluded from the territory and body politic of Australia. This article surveys and summarises these ideas and points to some of the recent redirections. These include a growing interest in the legacy of twentieth-century medico-legal border control on current (highly discriminating) regulations governing entry; a concern to make admissions under immigration and health law and regulation conceptually central; and the more familiar focus on race-based exclusions. Overall, my aim is to integrate the history of health and infectious disease control into the already extensive study of immigration and citizenship. Part of the effect of joint infectious disease and immigration regulation over the twentieth century has been the imagining, as well as the technical implementation of the island-nation as ostensibly secure, racially and territorially.