[Effects of weak solutions of aldehydes on EEG changes in rats]. / Vliianie slabykh rastvorov al'degidov na izmeneniia EEG krys.

Alternations of EEG have been investigated after single intraarterial infusion of formaldehyde, glutaric aldehyde and its mixture in 50 adult male rats. The dissolved solutions of aldehydes were shown to have complicated inhibitive activity which consists of two phases. The first phase of EEG inhibition rapidly develops and it isn't very long in its duration. The second one is much more durable. Formaldehyde causes the first phase of inhibition in general, though glutaric aldehyde promotes especially the appearance of the second phase. The mixture of two aldehydes demonstrates synergic activity which is shown as significant increase of EEG inhibition as compared to individual inhibitive activity of aldehydes. The inhibitive influence of aldehydes is fully reversible, nonspecific and doesn't cause post-experimental disorders. The highest effect of brain protection from ischaemia damages coincides with development of maximum inhibition of specific brain functions during the second phase of EEG depression.

[Optimization of conservation regimes and processes of regeneration of organs and tissues in surgery and transplantology using mathematical methods of planning experiments]. / Optimizatsiia rezhimov konservirovaniia i protsessov regeneratsii organov i tkanei v khirurgii i transplantologii s ispol'zovaniem matematicheskikh metodov planirovaniia éksperimenta.

The experience of using mathematical planning of an experiment in solving problems of multifactor optimisation in surgery and transplantology is discussed, including optimisation of heart and bone tissue preservation with low-dose aldehydes and antioxidants, study of the effects of retabolil on gastroenteroanastomosis regeneration, and optimisation of ischaemic damage prevention with low-dose aldehydes. In solving these problems, multifactor economical plans were initially applied to identify the optimal variants for several outputs. Second-order plans were further employed to specify the optimal regimes and construct models describing the optimum region. Recommendations on the choice of the most rational and time-saving regimes have been elaborated.

[Effect of formaldehyde on brain carbohydrate metabolism]. / Vliianie formal'degida na uglevodnyi obmen golovnogo mozga.

The use of formaldehyde makes it possible to decrease the speed of the energy metabolism in the brain without any significant pathological chemical changes in the functional state of the cardiovascular system. The given effect of formaldehyde may account for the attenuation of hypoxic and ischemic disturbances.

[Permeability of the blood-brain barrier to intra-arterial formaldehyde]. / O pronitsaemosti gematoéntsefalicheskogo bar'era dlia formal'degida pri ego vnutrisosudistom vvedenii.

Formaldehyde concentration was assessed in the brain, cerebrospinal liquor, arterial and venous blood of intact animals and following its intraarterial injections. It is concluded that formaldehyde is capable of penetrating through the blood-brain barrier, with the degree of permeability depending on blood formaldehyde concentration. The distribution of formaldehyde in the blood-brain-cerebrospinal liquor system suggests the presence of both protein-bound and unbound formaldehyde forms in the organism.